Diagnostic and Prognostic Value of the Parameters of Lipid Peroxidation and Endogenous Intoxication in Abdominal Sepsis

• Main Authors: O. V. Udakova, E. V. Grigoriev
• Format: Article
• Language: Russian
• Published: Russian Academy of Medical Sciences 2006-12-01
• Series: Obŝaâ Reanimatologiâ
• Subjects: abdominal sepsis; lipid peroxidation; endogenous intoxication; predictors
• Online Access: https://www.reanimatology.com/rmt/article/view/1376

The objective of the study was to assess the diagnostic and prognostic value of the parameters of lipid peroxidation and endogenous intoxication in abdominal sepsis. For this purpose, the authors conducted a prospective study of 36 patients diagnosed as having generalized peritonitis, abdominal sepsis. According to the clinical and laboratory characteristics of the severity of sepsis, the patients were divided into 3 groups. A group of patients with the manifestations of abdominal sepsis without organ dysfunction was characterized by the activation of lipid peroxidation, the high activity of antioxidant defense and the moderate level of endogenous intoxication markers. A group of patients with the manifestations of severe sepsis and multiple organ dysfunction showed high lipid peroxidation processes and lowered antioxidant activities. A group of patients with septic shock displayed accumulation of lipid peroxidation products and inhibition of activity of enzymatic antioxidants, and high levels of endogenous intoxication markers, which was followed by the highest mortality rates in the compared groups.