Zebrafish model for human gut microbiome-related studies: advantages and limitations

Germ-free models and bacterial transplantation technology facilitate the mechanism study of the host-gut microbe interaction. Among them, zebrafish is an economical and practical model with its characteristics, such as transparent larva and efficient gene manipulation, differing from the mouse. Here...

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Main Authors:	Hui Lu, Ping Li, Xiaochang Huang, Charles Hantsing Wang, Ming Li, Zhenjiang Zech Xu
Format:	Article
Language:	English
Published:	Elsevier 2021-06-01
Series:	Medicine in Microecology
Subjects:	Zebrafish Gut microbe Animal model
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590097821000100

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spelling	doaj-2284401cb9a043538ec55925325ba8982021-09-19T04:59:14ZengElsevierMedicine in Microecology2590-09782021-06-018100042Zebrafish model for human gut microbiome-related studies: advantages and limitationsHui Lu0Ping Li1Xiaochang Huang2Charles Hantsing Wang3Ming Li4Zhenjiang Zech Xu5State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330029, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330029, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330029, Jiangxi, ChinaSchool of Life Sciences, Nanchang University, Nanchang, 330031, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330029, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330029, Jiangxi, China; Corresponding author.Germ-free models and bacterial transplantation technology facilitate the mechanism study of the host-gut microbe interaction. Among them, zebrafish is an economical and practical model with its characteristics, such as transparent larva and efficient gene manipulation, differing from the mouse. Here we enumerate the similarities and differences of the genes, the digestive tract structure and the gut microbiota of zebrafish and humans. And the recent reports on colonizing human gut microbes to zebrafish are elaborated. We summarize the advantages and limitations of this model and revalidate those with some important discoveries on the utilization of zebrafish in modeling human gut microbe research. This review will make the readers clear the advances in the application of zebrafish in gut microbiota-related researches.http://www.sciencedirect.com/science/article/pii/S2590097821000100ZebrafishGut microbeAnimal model
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hui Lu Ping Li Xiaochang Huang Charles Hantsing Wang Ming Li Zhenjiang Zech Xu
spellingShingle	Hui Lu Ping Li Xiaochang Huang Charles Hantsing Wang Ming Li Zhenjiang Zech Xu Zebrafish model for human gut microbiome-related studies: advantages and limitations Medicine in Microecology Zebrafish Gut microbe Animal model
author_facet	Hui Lu Ping Li Xiaochang Huang Charles Hantsing Wang Ming Li Zhenjiang Zech Xu
author_sort	Hui Lu
title	Zebrafish model for human gut microbiome-related studies: advantages and limitations
title_short	Zebrafish model for human gut microbiome-related studies: advantages and limitations
title_full	Zebrafish model for human gut microbiome-related studies: advantages and limitations
title_fullStr	Zebrafish model for human gut microbiome-related studies: advantages and limitations
title_full_unstemmed	Zebrafish model for human gut microbiome-related studies: advantages and limitations
title_sort	zebrafish model for human gut microbiome-related studies: advantages and limitations
publisher	Elsevier
series	Medicine in Microecology
issn	2590-0978
publishDate	2021-06-01
description	Germ-free models and bacterial transplantation technology facilitate the mechanism study of the host-gut microbe interaction. Among them, zebrafish is an economical and practical model with its characteristics, such as transparent larva and efficient gene manipulation, differing from the mouse. Here we enumerate the similarities and differences of the genes, the digestive tract structure and the gut microbiota of zebrafish and humans. And the recent reports on colonizing human gut microbes to zebrafish are elaborated. We summarize the advantages and limitations of this model and revalidate those with some important discoveries on the utilization of zebrafish in modeling human gut microbe research. This review will make the readers clear the advances in the application of zebrafish in gut microbiota-related researches.
topic	Zebrafish Gut microbe Animal model
url	http://www.sciencedirect.com/science/article/pii/S2590097821000100
work_keys_str_mv	AT huilu zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations AT pingli zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations AT xiaochanghuang zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations AT charleshantsingwang zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations AT mingli zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations AT zhenjiangzechxu zebrafishmodelforhumangutmicrobiomerelatedstudiesadvantagesandlimitations
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Zebrafish model for human gut microbiome-related studies: advantages and limitations

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