Neuroprotective effects of statins against amyloid β-induced neurotoxicity
A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysre...
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2018-01-01
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doaj-22877bf82df34ce3b45599c47477b1f02020-11-25T03:53:40ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742018-01-0113219820610.4103/1673-5374.226379Neuroprotective effects of statins against amyloid β-induced neurotoxicityHsin-Hua LiChih-Li LinChien-Ning HuangA growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeostasis may increase the amyloid β (Aβ) levels by affecting amyloid precursor protein (APP) cleavage, which is the most important risk factor involved in the pathogenesis of AD. Previous research demonstrated that Aβ can trigger neuronal insulin resistance, which plays an important role in response to Aβ-induced neurotoxicity in AD. Epidemiological studies also suggested that statin use is associated with a decreased incidence of AD. Therefore, statins are believed to be a good candidate for conferring neuroprotective effects against AD. Statins may play a beneficial role in reducing Aβ-induced neurotoxicity. Their effect involves a putative mechanism beyond its cholesterol-lowering effects in preventing Aβ-induced neurotoxicity. However, the underlying molecular mechanisms of the protective effect of statins have not been clearly determined in Aβ-induced neurotoxicity. Given that statins may provide benefits beyond the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, these drugs may also improve the brain. Thus, statins may have beneficial effects on impaired insulin signaling by activating AMP-activated protein kinase (AMPK) in neuronal cells. They play a potential therapeutic role in targeting Aβ-mediated neurotoxicity.http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=2;spage=198;epage=206;aulast=Listatins; neuroprotective effects; amyloid β-induced neurotoxicity; insulin signaling; AMP-activated protein kinase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsin-Hua Li Chih-Li Lin Chien-Ning Huang |
spellingShingle |
Hsin-Hua Li Chih-Li Lin Chien-Ning Huang Neuroprotective effects of statins against amyloid β-induced neurotoxicity Neural Regeneration Research statins; neuroprotective effects; amyloid β-induced neurotoxicity; insulin signaling; AMP-activated protein kinase |
author_facet |
Hsin-Hua Li Chih-Li Lin Chien-Ning Huang |
author_sort |
Hsin-Hua Li |
title |
Neuroprotective effects of statins against amyloid β-induced neurotoxicity |
title_short |
Neuroprotective effects of statins against amyloid β-induced neurotoxicity |
title_full |
Neuroprotective effects of statins against amyloid β-induced neurotoxicity |
title_fullStr |
Neuroprotective effects of statins against amyloid β-induced neurotoxicity |
title_full_unstemmed |
Neuroprotective effects of statins against amyloid β-induced neurotoxicity |
title_sort |
neuroprotective effects of statins against amyloid β-induced neurotoxicity |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2018-01-01 |
description |
A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeostasis may increase the amyloid β (Aβ) levels by affecting amyloid precursor protein (APP) cleavage, which is the most important risk factor involved in the pathogenesis of AD. Previous research demonstrated that Aβ can trigger neuronal insulin resistance, which plays an important role in response to Aβ-induced neurotoxicity in AD. Epidemiological studies also suggested that statin use is associated with a decreased incidence of AD. Therefore, statins are believed to be a good candidate for conferring neuroprotective effects against AD. Statins may play a beneficial role in reducing Aβ-induced neurotoxicity. Their effect involves a putative mechanism beyond its cholesterol-lowering effects in preventing Aβ-induced neurotoxicity. However, the underlying molecular mechanisms of the protective effect of statins have not been clearly determined in Aβ-induced neurotoxicity. Given that statins may provide benefits beyond the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, these drugs may also improve the brain. Thus, statins may have beneficial effects on impaired insulin signaling by activating AMP-activated protein kinase (AMPK) in neuronal cells. They play a potential therapeutic role in targeting Aβ-mediated neurotoxicity. |
topic |
statins; neuroprotective effects; amyloid β-induced neurotoxicity; insulin signaling; AMP-activated protein kinase |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=2;spage=198;epage=206;aulast=Li |
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