K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter

K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter

We report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3...

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Bibliographic Details
Main Authors: Luca Bruni, Simonetta Croci
Format: Article
Language:English
Published: PAGEPress Publications 2014-01-01
Series:Journal of Biological Research
Subjects:
HTB-126 cell line, DNAzyme, cancer, K+ ion and D-ribose
Online Access:http://www.pagepressjournals.org/index.php/jbr/article/view/2135
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spelling doaj-2289419c66d2454fb2643e43400091f52020-11-25T03:34:16ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302014-01-0187110.4081/jbr.2014.21351428K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoterLuca Bruni0Simonetta Croci1Unit of Biophysics and Medical Physics, Department of Neuroscience, University of ParmaINBB National Institute of Biostructures and Biosystems, RomeWe report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3 and D-ribose from one side has a cytostatic effect on human breast cancer cell line increasing by 30% the doubling population time of treated cells with respect to the control; and on the other hand we demonstrate how it seems to permit the K+ uptake.http://www.pagepressjournals.org/index.php/jbr/article/view/2135HTB-126 cell line, DNAzyme, cancer, K+ ion and D-ribose
collection DOAJ
language English
format Article
sources DOAJ
author Luca Bruni
Simonetta Croci
spellingShingle Luca Bruni
Simonetta Croci
K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
Journal of Biological Research
HTB-126 cell line, DNAzyme, cancer, K+ ion and D-ribose
author_facet Luca Bruni
Simonetta Croci
author_sort Luca Bruni
title K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
title_short K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
title_full K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
title_fullStr K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
title_full_unstemmed K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
title_sort k:d-rib: cancer cell proliferation inibitor and dnazyme folding promoter
publisher PAGEPress Publications
series Journal of Biological Research
issn 1826-8838
2284-0230
publishDate 2014-01-01
description We report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3 and D-ribose from one side has a cytostatic effect on human breast cancer cell line increasing by 30% the doubling population time of treated cells with respect to the control; and on the other hand we demonstrate how it seems to permit the K+ uptake.
topic HTB-126 cell line, DNAzyme, cancer, K+ ion and D-ribose
url http://www.pagepressjournals.org/index.php/jbr/article/view/2135
work_keys_str_mv AT lucabruni kdribcancercellproliferationinibitoranddnazymefoldingpromoter
AT simonettacroci kdribcancercellproliferationinibitoranddnazymefoldingpromoter
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