Corticosterone Enhances the AMPK-Mediated Immunosuppressive Phenotype of Testicular Macrophages During Uropathogenic Escherichia coli Induced Orchitis

Corticosterone Enhances the AMPK-Mediated Immunosuppressive Phenotype of Testicular Macrophages During Uropathogenic Escherichia coli Induced Orchitis

Testicular macrophages (TM) play a central role in maintaining testicular immune privilege and protecting spermatogenesis. Recent studies showed that their immunosuppressive properties are maintained by corticosterone in the testicular interstitial fluid, but the underlying molecular mechanisms are...

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Bibliographic Details
Main Authors: Zhengguo Zhang, Ziming Jiang, Yiming Zhang, Yu Zhang, Yan Yan, Sudhanshu Bhushan, Andreas Meinhardt, Zhihai Qin, Ming Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
Corticosterone
Testicular macrophage
AMPK
Fatty acid oxidation (FAO)
Orchitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583276/full

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