Microbiome and Allergic Diseases
Allergic diseases, such as respiratory, cutaneous, and food allergy, have dramatically increased in prevalence over the last few decades. Recent research points to a central role of the microbiome, which is highly influenced by multiple environmental and dietary factors. It is well established that...
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doaj-229534c250fc480895f379af303e69452020-11-24T23:11:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01584382631Microbiome and Allergic DiseasesMariona Pascal0Marina Perez-Gordo1Marina Perez-Gordo2Teresa Caballero3Maria M. Escribese4M. Natividad Lopez Longo5Olga Luengo6Luis Manso7Victor Matheu8Elena Seoane9Miguel Zamorano10Moisés Labrador11Cristobalina Mayorga12Immunology Department, Centro de Diagnóstico Biomédico, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, ARADyAL, Barcelona, SpainBasic Medical Science Department, Faculty of Medicine, CEU San Pablo University, ARADyAL, Madrid, SpainInstitute of Applied and Molecular Medicine (IMMA), Faculty of Medicine, CEU San Pablo University, Madrid, SpainHospital Universitario La Paz, Madrid, SpainBasic Medical Science Department, Faculty of Medicine, CEU San Pablo University, ARADyAL, Madrid, SpainHospital Universitario de Araba, Vitoria, SpainHospital Vall d’Hebron, Barcelona, SpainHospital Universitario del Sureste, Madrid, SpainHospital Universitario de Canarias, Santa Cruz de Tenerife, SpainHospital Universitario Gregorio Marañón, Madrid, Spain0Hospital Universitario Ramón y Cajal, Madrid, SpainHospital Vall d’Hebron, Barcelona, Spain1Research Laboratory and Allergy Unit, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario, Universidad de Málaga, ARADyAL, Malaga, SpainAllergic diseases, such as respiratory, cutaneous, and food allergy, have dramatically increased in prevalence over the last few decades. Recent research points to a central role of the microbiome, which is highly influenced by multiple environmental and dietary factors. It is well established that the microbiome can modulate the immune response, from cellular development to organ and tissue formation exerting its effects through multiple interactions with both the innate and acquired branches of the immune system. It has been described at some extent changes in environment and nutrition produce dysbiosis in the gut but also in the skin, and lung microbiome, inducing qualitative and quantitative changes in composition and metabolic activity. Here, we review the potential role of the skin, respiratory, and gastrointestinal tract (GIT) microbiomes in allergic diseases. In the GIT, the microbiome has been proven to be important in developing either effector or tolerant responses to different antigens by balancing the activities of Th1 and Th2 cells. In the lung, the microbiome may play a role in driving asthma endotype polarization, by adjusting the balance between Th2 and Th17 patterns. Bacterial dysbiosis is associated with chronic inflammatory disorders of the skin, such as atopic dermatitis and psoriasis. Thus, the microbiome can be considered a therapeutical target for treating inflammatory diseases, such as allergy. Despite some limitations, interventions with probiotics, prebiotics, and/or synbiotics seem promising for the development of a preventive therapy by restoring altered microbiome functionality, or as an adjuvant in specific immunotherapy.https://www.frontiersin.org/article/10.3389/fimmu.2018.01584/fullmicrobiomemicrobiotaallergyallergic diseasesprebioticsprobiotics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariona Pascal Marina Perez-Gordo Marina Perez-Gordo Teresa Caballero Maria M. Escribese M. Natividad Lopez Longo Olga Luengo Luis Manso Victor Matheu Elena Seoane Miguel Zamorano Moisés Labrador Cristobalina Mayorga |
spellingShingle |
Mariona Pascal Marina Perez-Gordo Marina Perez-Gordo Teresa Caballero Maria M. Escribese M. Natividad Lopez Longo Olga Luengo Luis Manso Victor Matheu Elena Seoane Miguel Zamorano Moisés Labrador Cristobalina Mayorga Microbiome and Allergic Diseases Frontiers in Immunology microbiome microbiota allergy allergic diseases prebiotics probiotics |
author_facet |
Mariona Pascal Marina Perez-Gordo Marina Perez-Gordo Teresa Caballero Maria M. Escribese M. Natividad Lopez Longo Olga Luengo Luis Manso Victor Matheu Elena Seoane Miguel Zamorano Moisés Labrador Cristobalina Mayorga |
author_sort |
Mariona Pascal |
title |
Microbiome and Allergic Diseases |
title_short |
Microbiome and Allergic Diseases |
title_full |
Microbiome and Allergic Diseases |
title_fullStr |
Microbiome and Allergic Diseases |
title_full_unstemmed |
Microbiome and Allergic Diseases |
title_sort |
microbiome and allergic diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-07-01 |
description |
Allergic diseases, such as respiratory, cutaneous, and food allergy, have dramatically increased in prevalence over the last few decades. Recent research points to a central role of the microbiome, which is highly influenced by multiple environmental and dietary factors. It is well established that the microbiome can modulate the immune response, from cellular development to organ and tissue formation exerting its effects through multiple interactions with both the innate and acquired branches of the immune system. It has been described at some extent changes in environment and nutrition produce dysbiosis in the gut but also in the skin, and lung microbiome, inducing qualitative and quantitative changes in composition and metabolic activity. Here, we review the potential role of the skin, respiratory, and gastrointestinal tract (GIT) microbiomes in allergic diseases. In the GIT, the microbiome has been proven to be important in developing either effector or tolerant responses to different antigens by balancing the activities of Th1 and Th2 cells. In the lung, the microbiome may play a role in driving asthma endotype polarization, by adjusting the balance between Th2 and Th17 patterns. Bacterial dysbiosis is associated with chronic inflammatory disorders of the skin, such as atopic dermatitis and psoriasis. Thus, the microbiome can be considered a therapeutical target for treating inflammatory diseases, such as allergy. Despite some limitations, interventions with probiotics, prebiotics, and/or synbiotics seem promising for the development of a preventive therapy by restoring altered microbiome functionality, or as an adjuvant in specific immunotherapy. |
topic |
microbiome microbiota allergy allergic diseases prebiotics probiotics |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01584/full |
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