Bacillamidins A–G from a Marine-Derived Bacillus pumilus

Bacillamidins A–G from a Marine-Derived Bacillus pumilus

Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compou...

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Main Authors: Si-Yu Zhou, Yi-Jie Hu, Fan-Cheng Meng, Shen-Yue Qu, Rui Wang, Raymond J. Andersen, Zhi-Hua Liao, Min Chen
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Marine Drugs
Subjects:
Bacillus pumilus
long-chain amides
cytotoxic activity
antimicrobial activity
Online Access:http://www.mdpi.com/1660-3397/16/9/326
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spelling doaj-2295c7aa517d4d4c8476bbe3abdc86772020-11-24T21:14:36ZengMDPI AGMarine Drugs1660-33972018-09-0116932610.3390/md16090326md16090326Bacillamidins A–G from a Marine-Derived Bacillus pumilusSi-Yu Zhou0Yi-Jie Hu1Fan-Cheng Meng2Shen-Yue Qu3Rui Wang4Raymond J. Andersen5Zhi-Hua Liao6Min Chen7Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T1Z1, CanadaSchool of Life Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaSeven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.http://www.mdpi.com/1660-3397/16/9/326Bacillus pumiluslong-chain amidescytotoxic activityantimicrobial activity
collection DOAJ
language English
format Article
sources DOAJ
author Si-Yu Zhou
Yi-Jie Hu
Fan-Cheng Meng
Shen-Yue Qu
Rui Wang
Raymond J. Andersen
Zhi-Hua Liao
Min Chen
spellingShingle Si-Yu Zhou
Yi-Jie Hu
Fan-Cheng Meng
Shen-Yue Qu
Rui Wang
Raymond J. Andersen
Zhi-Hua Liao
Min Chen
Bacillamidins A–G from a Marine-Derived Bacillus pumilus
Marine Drugs
Bacillus pumilus
long-chain amides
cytotoxic activity
antimicrobial activity
author_facet Si-Yu Zhou
Yi-Jie Hu
Fan-Cheng Meng
Shen-Yue Qu
Rui Wang
Raymond J. Andersen
Zhi-Hua Liao
Min Chen
author_sort Si-Yu Zhou
title Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_short Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_full Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_fullStr Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_full_unstemmed Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_sort bacillamidins a–g from a marine-derived bacillus pumilus
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2018-09-01
description Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.
topic Bacillus pumilus
long-chain amides
cytotoxic activity
antimicrobial activity
url http://www.mdpi.com/1660-3397/16/9/326
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