CTLA-4 expression by B-1a B cells is essential for immune tolerance

CTLA-4 expression by B-1a B cells is essential for immune tolerance

CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.

Bibliographic Details
Main Authors: Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V. Youngyunpipatkul, James B. Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G. Vilches-Moure, Denong Wang, Michael P. Snyder, Ji-Yang Wang, Jian Han, Leonore A. Herzenberg
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20874-x

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