Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects

Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to...

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Main Authors: Mohamad Bakhtiar Hesam Shariati, Maryam Sohrabi, Siamak Shahidi, Ali Nikkhah, Fatemeh Mirzaei, Mehdi Medizadeh, Sara Soleimani Asl
Format: Article
Language:English
Published: Iran University of Medical Sciences 2014-07-01
Series:Basic and Clinical Neuroscience
Subjects:
Online Access:http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-212&slc_lang=en&sid=1
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spelling doaj-229a41a65fd848d59b20264394a27fd42020-11-25T00:59:43ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422014-07-0153225230Acute Effects of Ecstasy on Memory Are more Extensive than Chronic EffectsMohamad Bakhtiar Hesam Shariati0Maryam Sohrabi1Siamak Shahidi2Ali Nikkhah3Fatemeh Mirzaei4Mehdi Medizadeh5Sara Soleimani Asl6 Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Cellular & Molecular Research Center, Faculty of Advanced Technology in Medicne, Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, Iran Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoidance. Methods: Adult male Wistar rats (200-250 g) were given single or multiple injections of MDMA (10 mg/kg, IP). Using passive avoidance and Morris Water Maze (MWM) tasks, learning and spatial memory functions were assessed. The data were analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) test. Results: Our results showed that there were significant differences in latency to enter the dark compartment (STL) between sham and MDMA- treated groups. Acute group significantly showed more STL in comparison with chronic group. Furthermore, MDMA groups spent more time in dark compartment (TDS) than the sham group. Administration of single dose of MDMA significantly caused an increase in TDS compared with the chronic group. In the MWM, MDMA treatment significantly increased the traveled distance and escaped latency compared to the sham group. Like to passive avoidance task, percentage of time spent in the target quadrant in MDMA- treated animals impaired in MWM compared with sham group. Discussion: These data suggest that MDMA treatment impairs learning and memory functions that are more extensive in acute- treated rats.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-212&slc_lang=en&sid=1EcstasySpatial MemoryLearning.
collection DOAJ
language English
format Article
sources DOAJ
author Mohamad Bakhtiar Hesam Shariati
Maryam Sohrabi
Siamak Shahidi
Ali Nikkhah
Fatemeh Mirzaei
Mehdi Medizadeh
Sara Soleimani Asl
spellingShingle Mohamad Bakhtiar Hesam Shariati
Maryam Sohrabi
Siamak Shahidi
Ali Nikkhah
Fatemeh Mirzaei
Mehdi Medizadeh
Sara Soleimani Asl
Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
Basic and Clinical Neuroscience
Ecstasy
Spatial Memory
Learning.
author_facet Mohamad Bakhtiar Hesam Shariati
Maryam Sohrabi
Siamak Shahidi
Ali Nikkhah
Fatemeh Mirzaei
Mehdi Medizadeh
Sara Soleimani Asl
author_sort Mohamad Bakhtiar Hesam Shariati
title Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
title_short Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
title_full Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
title_fullStr Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
title_full_unstemmed Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects
title_sort acute effects of ecstasy on memory are more extensive than chronic effects
publisher Iran University of Medical Sciences
series Basic and Clinical Neuroscience
issn 2008-126X
2228-7442
publishDate 2014-07-01
description Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoidance. Methods: Adult male Wistar rats (200-250 g) were given single or multiple injections of MDMA (10 mg/kg, IP). Using passive avoidance and Morris Water Maze (MWM) tasks, learning and spatial memory functions were assessed. The data were analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) test. Results: Our results showed that there were significant differences in latency to enter the dark compartment (STL) between sham and MDMA- treated groups. Acute group significantly showed more STL in comparison with chronic group. Furthermore, MDMA groups spent more time in dark compartment (TDS) than the sham group. Administration of single dose of MDMA significantly caused an increase in TDS compared with the chronic group. In the MWM, MDMA treatment significantly increased the traveled distance and escaped latency compared to the sham group. Like to passive avoidance task, percentage of time spent in the target quadrant in MDMA- treated animals impaired in MWM compared with sham group. Discussion: These data suggest that MDMA treatment impairs learning and memory functions that are more extensive in acute- treated rats.
topic Ecstasy
Spatial Memory
Learning.
url http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-212&slc_lang=en&sid=1
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