BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION
Aim. Comparative evaluation of two biochemical markers of bone resorption and hormonal regulation of bone metabolism in liver recipients. Methods and results. Bоne densitometry of L2–L4 and neck of femur, serum level of some hormones (PTH, vitamin D3, estradiol, testosterone) regulating osteoclastog...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
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doaj-22a1fbffc7a649198351295a6796a1632021-07-29T09:08:26ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov Vestnik Transplantologii i Iskusstvennyh Organov1995-11912013-03-01151313810.15825/1995-1191-2013-1-31-3880BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATIONV. P. Buzulina0I. A. Pronchenko1I. P. Ermakova2N. P. Shmerko3M. N. Kornilov4E. B. Yaroshenko5T. K. Koliashvili6Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAim. Comparative evaluation of two biochemical markers of bone resorption and hormonal regulation of bone metabolism in liver recipients. Methods and results. Bоne densitometry of L2–L4 and neck of femur, serum level of some hormones (PTH, vitamin D3, estradiol, testosterone) regulating osteoclastogenesis as well as com- parative analyses of two bone resorption markers β-crosslaps and tartrate-resistant acid phosphatase type 5b (TRAP-5b) were fulfilled in patients after orthotopic liver transplantation (OLT). In 1 month after OLT bone density reduction of L2–L4 and neck of femur; decrease of vitamin D3, estradiol in women, testosterone in men and increase levels of bone resorption markers were observed. In 1 and 2 years after OLT the rise of bone density, increased levels of PTH, estradiol, testosterone and decreased β-crosslaps levels were revealed, while vitamin D3 and TRAP-5b levels remained stable. Conclusion. TRAP-5b was found to be a more speciffic marker of bone resorption, independent from collagen metabolism in liver. Osteoporosis defined in long-term period after OLT was associated with higher TRAP-5b and revialed in women with low estradiol level.https://journal.transpl.ru/vtio/article/view/137orthotopic liver transplantation, osteoporosis, markers of bone resorption |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V. P. Buzulina I. A. Pronchenko I. P. Ermakova N. P. Shmerko M. N. Kornilov E. B. Yaroshenko T. K. Koliashvili |
spellingShingle |
V. P. Buzulina I. A. Pronchenko I. P. Ermakova N. P. Shmerko M. N. Kornilov E. B. Yaroshenko T. K. Koliashvili BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION Vestnik Transplantologii i Iskusstvennyh Organov orthotopic liver transplantation, osteoporosis, markers of bone resorption |
author_facet |
V. P. Buzulina I. A. Pronchenko I. P. Ermakova N. P. Shmerko M. N. Kornilov E. B. Yaroshenko T. K. Koliashvili |
author_sort |
V. P. Buzulina |
title |
BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION |
title_short |
BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION |
title_full |
BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION |
title_fullStr |
BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION |
title_full_unstemmed |
BIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATION |
title_sort |
biochemical markers of bone resorption and hormonal regulation of bone metabolism following liver transplantation |
publisher |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
series |
Vestnik Transplantologii i Iskusstvennyh Organov |
issn |
1995-1191 |
publishDate |
2013-03-01 |
description |
Aim. Comparative evaluation of two biochemical markers of bone resorption and hormonal regulation of bone metabolism in liver recipients. Methods and results. Bоne densitometry of L2–L4 and neck of femur, serum level of some hormones (PTH, vitamin D3, estradiol, testosterone) regulating osteoclastogenesis as well as com- parative analyses of two bone resorption markers β-crosslaps and tartrate-resistant acid phosphatase type 5b (TRAP-5b) were fulfilled in patients after orthotopic liver transplantation (OLT). In 1 month after OLT bone density reduction of L2–L4 and neck of femur; decrease of vitamin D3, estradiol in women, testosterone in men and increase levels of bone resorption markers were observed. In 1 and 2 years after OLT the rise of bone density, increased levels of PTH, estradiol, testosterone and decreased β-crosslaps levels were revealed, while vitamin D3 and TRAP-5b levels remained stable. Conclusion. TRAP-5b was found to be a more speciffic marker of bone resorption, independent from collagen metabolism in liver. Osteoporosis defined in long-term period after OLT was associated with higher TRAP-5b and revialed in women with low estradiol level. |
topic |
orthotopic liver transplantation, osteoporosis, markers of bone resorption |
url |
https://journal.transpl.ru/vtio/article/view/137 |
work_keys_str_mv |
AT vpbuzulina biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT iapronchenko biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT ipermakova biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT npshmerko biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT mnkornilov biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT ebyaroshenko biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation AT tkkoliashvili biochemicalmarkersofboneresorptionandhormonalregulationofbonemetabolismfollowinglivertransplantation |
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