Neurocysticercosis in Children with Seizures: A Cross-Sectional Study
Background. Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics amo...
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doaj-22a8e96ae57143889989eea9b61fc84b2020-11-24T21:09:09ZengHindawi LimitedInternational Journal of Pediatrics1687-97401687-97592018-01-01201810.1155/2018/10308781030878Neurocysticercosis in Children with Seizures: A Cross-Sectional StudyMurli Manohar Gupta0Nagendra Chaudhary1Santosh Pathak2Nikhil Agrawal3Jaydev Yadav4Sandeep Shrestha5Om Prakash Kurmi6Baldev Bhatia7Kailash Nath Agarwal8Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalChitwan Medical College, Bharatpur 44200, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalCentre for Population Health and Research (CPR), Bhairahawa 32900, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalDepartment of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, NepalBackground. Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal. Aims and Objectives. To study the prevalence and clinical characteristics of NCC in children with seizures. Material and Methods. All children admitted to Universal College of Medical Sciences, a tertiary hospital in South-Western Nepal with seizures during 2014–16, were tested for NCC. NCC was diagnosed by neuroimaging [computerized tomography (CT) scan or magnetic resonance imaging (MRI)]. We used logistic regression to test the association between NCC with participants’ characteristics and clinical symptoms. Results. Among 4962 in-patient children, 168 (104 boys and 64 girls) had seizures (138 with generalized tonic clonic seizures (GTCS) and 30 with focal seizures). 43% of children with seizures had CT scan confirmed NCC. The prevalence of NCC in the oldest children (13–16 years) was significantly greater (57.1% versus 15.6%) compared to the youngest (0–4 years) one (p<0.001). Among 72 children with NCC, the proportions of children with vesicular, calcified, and colloidal stages were 76% (n=35), 18% (n=13), and 6% (n=2), respectively. Children with focal seizures had 13% more NCC compared to those with GTCS but the result was statistically not significant. The adjusted odds of having NCC among 5–8 years, 9–12 years, and 13–16 years children were 6.6 (1.78–24.60), 11.06 (2.74–44.60), and 14.47 (3.13–66.96), respectively, compared to 0–4-year-old children. Reoccurrence of seizures within the first 3 months of taking antiepileptic drug in those with NCC was approximately 3 times higher compared to those without NCC (11% versus 4%, p=0.084). Conclusions. This study shows that NCC contributes significantly to higher prevalence of seizures in children in South-Western region of Nepal.http://dx.doi.org/10.1155/2018/1030878 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murli Manohar Gupta Nagendra Chaudhary Santosh Pathak Nikhil Agrawal Jaydev Yadav Sandeep Shrestha Om Prakash Kurmi Baldev Bhatia Kailash Nath Agarwal |
spellingShingle |
Murli Manohar Gupta Nagendra Chaudhary Santosh Pathak Nikhil Agrawal Jaydev Yadav Sandeep Shrestha Om Prakash Kurmi Baldev Bhatia Kailash Nath Agarwal Neurocysticercosis in Children with Seizures: A Cross-Sectional Study International Journal of Pediatrics |
author_facet |
Murli Manohar Gupta Nagendra Chaudhary Santosh Pathak Nikhil Agrawal Jaydev Yadav Sandeep Shrestha Om Prakash Kurmi Baldev Bhatia Kailash Nath Agarwal |
author_sort |
Murli Manohar Gupta |
title |
Neurocysticercosis in Children with Seizures: A Cross-Sectional Study |
title_short |
Neurocysticercosis in Children with Seizures: A Cross-Sectional Study |
title_full |
Neurocysticercosis in Children with Seizures: A Cross-Sectional Study |
title_fullStr |
Neurocysticercosis in Children with Seizures: A Cross-Sectional Study |
title_full_unstemmed |
Neurocysticercosis in Children with Seizures: A Cross-Sectional Study |
title_sort |
neurocysticercosis in children with seizures: a cross-sectional study |
publisher |
Hindawi Limited |
series |
International Journal of Pediatrics |
issn |
1687-9740 1687-9759 |
publishDate |
2018-01-01 |
description |
Background. Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal. Aims and Objectives. To study the prevalence and clinical characteristics of NCC in children with seizures. Material and Methods. All children admitted to Universal College of Medical Sciences, a tertiary hospital in South-Western Nepal with seizures during 2014–16, were tested for NCC. NCC was diagnosed by neuroimaging [computerized tomography (CT) scan or magnetic resonance imaging (MRI)]. We used logistic regression to test the association between NCC with participants’ characteristics and clinical symptoms. Results. Among 4962 in-patient children, 168 (104 boys and 64 girls) had seizures (138 with generalized tonic clonic seizures (GTCS) and 30 with focal seizures). 43% of children with seizures had CT scan confirmed NCC. The prevalence of NCC in the oldest children (13–16 years) was significantly greater (57.1% versus 15.6%) compared to the youngest (0–4 years) one (p<0.001). Among 72 children with NCC, the proportions of children with vesicular, calcified, and colloidal stages were 76% (n=35), 18% (n=13), and 6% (n=2), respectively. Children with focal seizures had 13% more NCC compared to those with GTCS but the result was statistically not significant. The adjusted odds of having NCC among 5–8 years, 9–12 years, and 13–16 years children were 6.6 (1.78–24.60), 11.06 (2.74–44.60), and 14.47 (3.13–66.96), respectively, compared to 0–4-year-old children. Reoccurrence of seizures within the first 3 months of taking antiepileptic drug in those with NCC was approximately 3 times higher compared to those without NCC (11% versus 4%, p=0.084). Conclusions. This study shows that NCC contributes significantly to higher prevalence of seizures in children in South-Western region of Nepal. |
url |
http://dx.doi.org/10.1155/2018/1030878 |
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