Cytotoxic Isobractatin (Prenylated Xanthone) Epimer Mixture of <i>Garcinia eugenifolia</i>

• Main Authors: Sri Hartati, I Ketut Triyono, Sri Handayani
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2014-10-01
• Series: Indonesian Journal of Chemistry
• Subjects: Garcinia eugenifolia; isobractatin; epimer; breast cancer; T47D cells
• Online Access: https://jurnal.ugm.ac.id/ijc/article/view/21239

In search of bioactive anti-cancer compounds from natural products has been found isobractatin from n-hexane extract of Garcinia eugenifolia. Isolation was done through the stages of maceration and column chromatography. Elucidation of the structure was analyzed by spectroscopy of UV-Vis, FTIR, LC-MS, NMR proton and carbon one and two dimension data. The results found three compounds isolated from G. eugenifolia. The three compounds were stigmasterol, prenylated xanthone isobractatin and its epimer (in a mixture). The mixture of isobractatin and its epimer showed cytotoxic activity against breast cancer cell line T47D with IC50 = 17 µg/mL.