Genetics of symptom remission in outpatients with COVID-19
Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic pep...
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2021-05-01
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doaj-22ad144ba1304827b38809d5ea8a96062021-05-30T11:37:14ZengNature Publishing GroupScientific Reports2045-23222021-05-0111111010.1038/s41598-021-90365-6Genetics of symptom remission in outpatients with COVID-19Marie-Pierre Dubé0Audrey Lemaçon1Amina Barhdadi2Louis-Philippe Lemieux Perreault3Essaïd Oussaïd4Géraldine Asselin5Sylvie Provost6Maxine Sun7Johanna Sandoval8Marc-André Legault9Ian Mongrain10Anick Dubois11Diane Valois12Emma Dedelis13Jennifer Lousky14Julie Choi15Elisabeth Goulet16Christiane Savard17Lea-Mei Chicoine18Mariève Cossette19Malorie Chabot-Blanchet20Marie-Claude Guertin21Simon de Denus22Nadia Bouabdallaoui23Richard Marchand24Zohar Bassevitch25Anna Nozza26Daniel Gaudet27Philippe L. L’Allier28Julie Hussin29Guy Boivin30David Busseuil31Jean-Claude Tardif32Montreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteMontreal Heart InstituteEcogene-21 and Department of Medicine, Université de MontréalMontreal Heart InstituteMontreal Heart InstituteCentre Hospitalier de l’Université LavalMontreal Heart InstituteMontreal Heart InstituteAbstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic peptide receptor 3 gene (NPR3). By day 15 of the study, 44%, 54% and 59% of participants with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. In 851 participants not treated with colchicine (placebo), there was a significant association at 9q33.1 (rs62575331; P = 2.95 × 10–8) in interaction with colchicine (P = 1.19 × 10–5) without impact on risk of hospitalisations, highlighting a possibly shared mechanistic pathway. By day 15 of the study, 46%, 62% and 64% of those with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. The findings need to be replicated and could contribute to the biological understanding of COVID-19 symptom remission.https://doi.org/10.1038/s41598-021-90365-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif |
spellingShingle |
Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif Genetics of symptom remission in outpatients with COVID-19 Scientific Reports |
author_facet |
Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif |
author_sort |
Marie-Pierre Dubé |
title |
Genetics of symptom remission in outpatients with COVID-19 |
title_short |
Genetics of symptom remission in outpatients with COVID-19 |
title_full |
Genetics of symptom remission in outpatients with COVID-19 |
title_fullStr |
Genetics of symptom remission in outpatients with COVID-19 |
title_full_unstemmed |
Genetics of symptom remission in outpatients with COVID-19 |
title_sort |
genetics of symptom remission in outpatients with covid-19 |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-05-01 |
description |
Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic peptide receptor 3 gene (NPR3). By day 15 of the study, 44%, 54% and 59% of participants with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. In 851 participants not treated with colchicine (placebo), there was a significant association at 9q33.1 (rs62575331; P = 2.95 × 10–8) in interaction with colchicine (P = 1.19 × 10–5) without impact on risk of hospitalisations, highlighting a possibly shared mechanistic pathway. By day 15 of the study, 46%, 62% and 64% of those with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. The findings need to be replicated and could contribute to the biological understanding of COVID-19 symptom remission. |
url |
https://doi.org/10.1038/s41598-021-90365-6 |
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