Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin
Abstract Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The...
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doaj-22b3cc0c6c27415b8b948cdb00e8ba162020-11-25T02:27:48ZengBMCLaboratory Animal Research2233-76602016-12-01321465510.5625/lar.2016.32.1.46Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia originKangmoo Choi0Jaejin Chang1Min-Jae Lee2Seungsu Wang3Kimhong In4Wilhelm C. Galano-tan5Sanghun Jun6Kahee Cho7Yong-Hwa Hwang8Sung-Ju Kim9Wanje Park10Haeeun Life Science Research Institute, Orient Bio Inc.Haeeun Life Science Research Institute, Orient Bio Inc.Department of Veterinary Medicine, Kangwon National UniversityProduction, Orient Cam Co., Ltd.Production, Orient Cam Co., Ltd.Production, Orient Cam Co., Ltd.Haeeun Biomedical Research Institute, Genia Inc.Haeeun Biomedical Research Institute, Genia Inc.Haeeun Biomedical Research Institute, Genia Inc.Samsung Medical Center, Samsung Biomedical Research InstituteHaeeun Biomedical Research Institute, Genia Inc.Abstract Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models. Moreover, the biological parameters could be different according to the origin of the Cynomolgus monkey. However, there are limited references provided, especially of Cambodia origin. In this study, we measured average body weight of 2,518 Cynomolgus monkeys and analyzed hematology and serum biochemistry using 119 males, and determined blood types in 642 monkeys with Cambodia origin. The average body weight of male Cynomolgus monkeys were 2.56±0.345 kg and female group was 2.43± 0.330 kg at the age from 2 to 3 years. The male group showed relatively sharp increased average body weight from the 3 to 4 age period compared to the female group. In hematology and biochemistry, it was found that most of the data was similar when compared to other references even though some results showed differences. The ABO blood type result showed that type A, B, AB, and O was approximately 15.6, 33.3, 44.2, and 6.9%, respectively. The main blood type in this facility was B and AB. These biological background references of Cambodia origin could be used to provide important information to researchers who are using them in their biomedical research.http://link.springer.com/article/10.5625/lar.2016.32.1.46Cynomolgus monkeycambodia originbody weighthematologyserum biochemistryblood type |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kangmoo Choi Jaejin Chang Min-Jae Lee Seungsu Wang Kimhong In Wilhelm C. Galano-tan Sanghun Jun Kahee Cho Yong-Hwa Hwang Sung-Ju Kim Wanje Park |
spellingShingle |
Kangmoo Choi Jaejin Chang Min-Jae Lee Seungsu Wang Kimhong In Wilhelm C. Galano-tan Sanghun Jun Kahee Cho Yong-Hwa Hwang Sung-Ju Kim Wanje Park Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin Laboratory Animal Research Cynomolgus monkey cambodia origin body weight hematology serum biochemistry blood type |
author_facet |
Kangmoo Choi Jaejin Chang Min-Jae Lee Seungsu Wang Kimhong In Wilhelm C. Galano-tan Sanghun Jun Kahee Cho Yong-Hwa Hwang Sung-Ju Kim Wanje Park |
author_sort |
Kangmoo Choi |
title |
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
title_short |
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
title_full |
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
title_fullStr |
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
title_full_unstemmed |
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
title_sort |
reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin |
publisher |
BMC |
series |
Laboratory Animal Research |
issn |
2233-7660 |
publishDate |
2016-12-01 |
description |
Abstract Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models. Moreover, the biological parameters could be different according to the origin of the Cynomolgus monkey. However, there are limited references provided, especially of Cambodia origin. In this study, we measured average body weight of 2,518 Cynomolgus monkeys and analyzed hematology and serum biochemistry using 119 males, and determined blood types in 642 monkeys with Cambodia origin. The average body weight of male Cynomolgus monkeys were 2.56±0.345 kg and female group was 2.43± 0.330 kg at the age from 2 to 3 years. The male group showed relatively sharp increased average body weight from the 3 to 4 age period compared to the female group. In hematology and biochemistry, it was found that most of the data was similar when compared to other references even though some results showed differences. The ABO blood type result showed that type A, B, AB, and O was approximately 15.6, 33.3, 44.2, and 6.9%, respectively. The main blood type in this facility was B and AB. These biological background references of Cambodia origin could be used to provide important information to researchers who are using them in their biomedical research. |
topic |
Cynomolgus monkey cambodia origin body weight hematology serum biochemistry blood type |
url |
http://link.springer.com/article/10.5625/lar.2016.32.1.46 |
work_keys_str_mv |
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