Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells

Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells

The insensitivity of hepatocellular carcinoma to chemotherapy is associated with alternation in tumor cell cycling. This current study was designed to investigate the impact of p15 silencing on the sensitivity of Human hepatocellular carcinoma HepG2 cells to cisplatin. HepG2/CDDP/1.6 and HepG2/CDDP/...

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Bibliographic Details
Main Authors: Dianliang Fang, Yuanhong Guo, Zhenshuang Zhu, Weiqing Chen
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2012-02-01
Series:Bosnian Journal of Basic Medical Sciences
Subjects:
hepatocellular carcinoma
cell cycle
p15
RNA interference
drug resistance
Online Access:http://www.bjbms.org/ojs/index.php/bjbms/article/view/2523

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