A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity.

A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity.

The maintenance of genomic stability requires accurate genome replication, repair of DNA damage, and the precise segregation of chromosomes in mitosis. GEN1 possesses Holliday junction resolvase activity in vitro and presumably functions in homology driven repair of DNA double strand breaks. However...

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Bibliographic Details
Main Authors: Min Gao, Jannie Rendtlew Danielsen, Lei-Zhen Wei, Dong-Ping Zhou, Qian Xu, Miao-Miao Li, Zhao-Qi Wang, Wei-Min Tong, Yun-Gui Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3500319?pdf=render

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