Cephalosporins Interfere With Quorum Sensing and Improve the Ability of Caenorhabditis elegans to Survive Pseudomonas aeruginosa Infection

Cephalosporins Interfere With Quorum Sensing and Improve the Ability of Caenorhabditis elegans to Survive Pseudomonas aeruginosa Infection

Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins’ anti-QS activity using Chrom...

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Bibliographic Details
Main Authors: Lokender Kumar, Nathanael Brenner, John Brice, Judith Klein-Seetharaman, Susanta K. Sarkar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
cephalosporins
quorum sensing (QS)
biofilm
molecular docking
Caenorhabditis elegans
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.598498/full

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