| Summary: | Background: Endophytic fungi have economic potential as enzymes, medicines and biological
control agents. Cladosporium oxysporum endophytic fungi can be isolated from a plant named
Aglaia odorata Lour (Indonesian: Pacar Cina). This plant can be found in Purwodadi Botanical
Garden, Pasuruan, East Java. This study aimed to assess the antimicrobial activity from the ethyl
acetate extract of the Cladosporium oxysporum endophytic fungi against Escherichia coli,
Staphylococcus aureus, and Candida albicans.
Subjects and Method:This was a descriptive study. C. oxysporum was cultivated, extracted, and
fractionated. The fractions then were applied to antimicrobial activity assay. Disc diffusion method
was used in this project with 2 mg/disc concentration extracts.
Results: Some fractions of ethyl acetate extracts C.oxysporum showed antimicrobial activity
against all microbials tested. 6 of 13 fractions exhibited inhibition zone against S. aureusATCC
6538, E. coli ATCC 8739, and C. albicansATCC 10231. The seventh fraction exhibited the highest
inhibition zone against S. aureus ATCC 6538, and C.albicans ATCC 10231.The tenth fraction
exhibit edthe highest zone against E. coli ATCC 8739.
Conclusion: Cladosporium oxysporum from Aglaia odorata could be a good source of antimicrobial
substance. It produces bioactiveagent that can be developed into a new drug at a larger
commercial scale.
Keywords: endophytic fungi, cladosporium oxysporum, aglaia odorata lour, antimicrobial
activity
Correspondence:
Noor Erma Sugijanto, Bella Lexmita Dorra. Faculty of Pharmacy, Airlangga University.
|
|---|
