Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing

Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing

Abstract Background We benchmarked the hybrid assembly approaches of MaSuRCA, SPAdes, and Unicycler for bacterial pathogens using Illumina and Oxford Nanopore sequencing by determining genome completeness and accuracy, antimicrobial resistance (AMR), virulence potential, multilocus sequence typing (...

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Bibliographic Details
Main Authors: Zhao Chen, David L. Erickson, Jianghong Meng
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Genomics
Subjects:
Illumina sequencing
Oxford Nanopore sequencing
Hybrid assembly
MaSuRCA
SPAdes
Unicycler
Online Access:http://link.springer.com/article/10.1186/s12864-020-07041-8

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