SynGAP isoforms differentially regulate synaptic plasticity and dendritic development
SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal splice variants: α1, α2, β, and γ. Although studies have implicated SYNGAP1 in several cognitive disorders, it is not clear which SynGAP isoforms contribute to disease. Here, we demonstrate that SynGAP isoforms exhibit uni...
Main Authors: | Yoichi Araki, Ingie Hong, Timothy R Gamache, Shaowen Ju, Leonardo Collado-Torres, Joo Heon Shin, Richard L Huganir |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/56273 |
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