The role of B cell osteoimmunity in periodontitis

• Main Authors: LIN Xiaoping, HAN Yakun
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2020-04-01
• Series: 口腔疾病防治
• Subjects: periodontits; b cell; osteoimmunity; cytokine; bone absorption; transcription factor; nuclear factor kappa-b ligand receptor activator; interferon-γ; interleukin-17; interleukin-10
• Online Access: http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2020.04.001

As the most important pathological feature of periodontitis, alveolar bone resorption also results in tooth loss and oral dysfunction. According to recent research, the host immune response is the major factor leading to alveolar bone resorption. Antibodies, immune cells and inflammatory cytokines involved in this procedure cause an imbalance of bone formation and destruction, which is called osteoimmunity. Given the importance of adaptive humoral immunity during periodontitis, B cells are considered crucial in the development of periodontitis. Therefore, establishing B cell osteoimmunity is an effective way for us to deeply assess the start, development and prognosis of periodontitis. It has been proven that the development process of B cells is accompanied by changes in bone density or morphology. We have reviewed previous literature to understand the role of B cell bone immunity in the pathological process of periodontitis, and the results showed that B cells regulate the development of bone cell lines through transcription factors (such as RANKL, PU.1, E2A, etc.). In addition, various cytokines expressed by B cells (such as IFN-γ, IL-17, IL-10, TGF-β, etc.) can participate in the regulation of bone cells.