Counterregulation of cAMP-directed kinase activities controls ciliogenesis

The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.

Bibliographic Details
Main Authors:	Monia Porpora, Simona Sauchella, Laura Rinaldi, Rossella Delle Donne, Maria Sepe, Omar Torres-Quesada, Daniela Intartaglia, Corrado Garbi, Luigi Insabato, Margherita Santoriello, Verena A. Bachmann, Matthis Synofzik, Herbert H. Lindner, Ivan Conte, Eduard Stefan, Antonio Feliciello
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03643-9

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spelling	doaj-23040612179646c4bd606c5eb5df82fa2021-05-11T09:55:38ZengNature Publishing GroupNature Communications2041-17232018-03-019111310.1038/s41467-018-03643-9Counterregulation of cAMP-directed kinase activities controls ciliogenesisMonia Porpora0Simona Sauchella1Laura Rinaldi2Rossella Delle Donne3Maria Sepe4Omar Torres-Quesada5Daniela Intartaglia6Corrado Garbi7Luigi Insabato8Margherita Santoriello9Verena A. Bachmann10Matthis Synofzik11Herbert H. Lindner12Ivan Conte13Eduard Stefan14Antonio Feliciello15Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of InnsbruckTelethon Institute of Genetics and MedicineDepartment of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Department of Advanced Biomedical Sciences, University Federico IIDepartment of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of InnsbruckDepartment of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen and German Center for Neurodegenerative Diseases (DZNE)Division of Clinical Biochemistry, Biocenter Medical University of InnsbruckTelethon Institute of Genetics and MedicineInstitute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of InnsbruckDepartment of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.https://doi.org/10.1038/s41467-018-03643-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Monia Porpora Simona Sauchella Laura Rinaldi Rossella Delle Donne Maria Sepe Omar Torres-Quesada Daniela Intartaglia Corrado Garbi Luigi Insabato Margherita Santoriello Verena A. Bachmann Matthis Synofzik Herbert H. Lindner Ivan Conte Eduard Stefan Antonio Feliciello
spellingShingle	Monia Porpora Simona Sauchella Laura Rinaldi Rossella Delle Donne Maria Sepe Omar Torres-Quesada Daniela Intartaglia Corrado Garbi Luigi Insabato Margherita Santoriello Verena A. Bachmann Matthis Synofzik Herbert H. Lindner Ivan Conte Eduard Stefan Antonio Feliciello Counterregulation of cAMP-directed kinase activities controls ciliogenesis Nature Communications
author_facet	Monia Porpora Simona Sauchella Laura Rinaldi Rossella Delle Donne Maria Sepe Omar Torres-Quesada Daniela Intartaglia Corrado Garbi Luigi Insabato Margherita Santoriello Verena A. Bachmann Matthis Synofzik Herbert H. Lindner Ivan Conte Eduard Stefan Antonio Feliciello
author_sort	Monia Porpora
title	Counterregulation of cAMP-directed kinase activities controls ciliogenesis
title_short	Counterregulation of cAMP-directed kinase activities controls ciliogenesis
title_full	Counterregulation of cAMP-directed kinase activities controls ciliogenesis
title_fullStr	Counterregulation of cAMP-directed kinase activities controls ciliogenesis
title_full_unstemmed	Counterregulation of cAMP-directed kinase activities controls ciliogenesis
title_sort	counterregulation of camp-directed kinase activities controls ciliogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.
url	https://doi.org/10.1038/s41467-018-03643-9
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Counterregulation of cAMP-directed kinase activities controls ciliogenesis

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