The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes
Background: We analyzed cardiovascular inflammatory (Creactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic st...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Society of Medical Biochemists of Serbia, Belgrade
2019-01-01
|
Series: | Journal of Medical Biochemistry |
Subjects: | |
Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581902126P.pdf |
id |
doaj-23068909f85a479780cf9e8ecafcc5d3 |
---|---|
record_format |
Article |
spelling |
doaj-23068909f85a479780cf9e8ecafcc5d32020-11-25T02:09:59ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662019-01-013821261331452-82581902126PThe inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetesPopović Dragana0Lalić Katarina1https://orcid.org/0000-0002-8070-1899Jotić Aleksandra2Miličić Tanja3Bogdanović Jelena4Đorđević Maja5Stanković Sanja6https://orcid.org/0000-0003-3142-9902Jeremić Veljko7https://orcid.org/0000-0002-7761-1841Lalić Nebojša M.8University of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeUniversity of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeUniversity of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeUniversity of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeUniversity of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeClinical Center of Serbia, Emergency Center, BelgradeClinical Center of Serbia, Center for Medical Biochemistry, BelgradeUniversity of Belgrade, Faculty of Organizational Sciences, Department for Operations Research and Statistics, BelgradeUniversity of Belgrade, Faculty of Medicine, Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, BelgradeBackground: We analyzed cardiovascular inflammatory (Creactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = 10 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N = 15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results: Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p< 0.001; B: p< 0.001, C: p< 0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p < 0.001; C: p<0.05, D: p=0.001 pmol/L), respectively, at resolving AHC. However, CRP persisted higher (p< 0.001, p< 0.01), IL-6 lower (p< 0.05, p< 0.001), while homocysteine levels turned out to be similar to controls. Conclusions: AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581902126P.pdfacute hyperglycemic crisiscardiovascular risk markersinflammatory markershaemostatic markers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Popović Dragana Lalić Katarina Jotić Aleksandra Miličić Tanja Bogdanović Jelena Đorđević Maja Stanković Sanja Jeremić Veljko Lalić Nebojša M. |
spellingShingle |
Popović Dragana Lalić Katarina Jotić Aleksandra Miličić Tanja Bogdanović Jelena Đorđević Maja Stanković Sanja Jeremić Veljko Lalić Nebojša M. The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes Journal of Medical Biochemistry acute hyperglycemic crisis cardiovascular risk markers inflammatory markers haemostatic markers |
author_facet |
Popović Dragana Lalić Katarina Jotić Aleksandra Miličić Tanja Bogdanović Jelena Đorđević Maja Stanković Sanja Jeremić Veljko Lalić Nebojša M. |
author_sort |
Popović Dragana |
title |
The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
title_short |
The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
title_full |
The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
title_fullStr |
The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
title_full_unstemmed |
The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
title_sort |
inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes |
publisher |
Society of Medical Biochemists of Serbia, Belgrade |
series |
Journal of Medical Biochemistry |
issn |
1452-8258 1452-8266 |
publishDate |
2019-01-01 |
description |
Background: We analyzed cardiovascular inflammatory (Creactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = 10 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N = 15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results: Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p< 0.001; B: p< 0.001, C: p< 0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p < 0.001; C: p<0.05, D: p=0.001 pmol/L), respectively, at resolving AHC. However, CRP persisted higher (p< 0.001, p< 0.01), IL-6 lower (p< 0.05, p< 0.001), while homocysteine levels turned out to be similar to controls. Conclusions: AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP. |
topic |
acute hyperglycemic crisis cardiovascular risk markers inflammatory markers haemostatic markers |
url |
https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581902126P.pdf |
work_keys_str_mv |
AT popovicdragana theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT lalickatarina theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT joticaleksandra theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT milicictanja theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT bogdanovicjelena theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT đorđevicmaja theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT stankovicsanja theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT jeremicveljko theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT lalicnebojsam theinflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT popovicdragana inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT lalickatarina inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT joticaleksandra inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT milicictanja inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT bogdanovicjelena inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT đorđevicmaja inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT stankovicsanja inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT jeremicveljko inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes AT lalicnebojsam inflammatoryandhemostaticcardiovascularriskmarkersduringacutehyperglycemiccrisisintype1andtype2diabetes |
_version_ |
1724921269528297472 |