<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption
We determined the association between <i>T. gondii</i> infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti-<i>T. gondii</i> IgG a...
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doaj-231414e0e5aa42658e634ec2acd842422021-06-30T23:51:49ZengMDPI AGPathogens2076-08172021-06-011073473410.3390/pathogens10060734<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol ConsumptionCosme Alvarado-Esquivel0Sergio Estrada-Martínez1Alma Rosa Pérez-Álamos2Isabel Beristain-García3Ángel Osvaldo Alvarado-Félix4Gustavo Alexis Alvarado-Félix5Antonio Sifuentes-Álvarez6Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoInstitute for Scientific Research “Dr. Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoInstitute for Scientific Research “Dr. Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoFacultad de Enfermería y Obstetricia, Juárez University of Durango State, Blvd. Juan Pablo II 512, Durango 34000, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoWe determined the association between <i>T. gondii</i> infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti-<i>T. gondii</i> IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Anti-<i>T. gondii</i> IgG antibodies were found in 34 of 224 (15.2%) individuals with suicidal ideation and in 118 (9.8%) of 1199 individuals without suicidal ideation (OR: 1.63; 95% CI: 1.08–2.47; <i>p</i> = 0.01). Seropositivity to <i>T. gondii</i> was associated with suicidal ideation in women (OR: 2.24; 95% CI: 1.33–3.78; <i>p</i> = 0.001) and in individuals aged ≤30 years (OR: 2.68; 95% CI: 1.22–5.87; <i>p</i> = 0.01) and >50 years (OR: 2.85; 95% CI: 1.19–6.77; <i>p</i> = 0.01). Anti-<i>T. gondii</i> IgG antibodies were found in 17 of 136 (12.5%) individuals with suicide attempts and in 135 (10.5%) of 1287 individuals without suicide attempts (OR: 1.21; 95% CI: 0.71–2.08; <i>p</i> = 0.47). Seroprevalence of <i>T. gondii</i> infection was associated with suicide attempts in women (OR: 1.88; 95% CI: 0.99–3.55; <i>p</i> = 0.04). No association between anti-<i>T. gondii</i> IgM and suicidal ideation or suicide attempts was found. Results suggest that <i>T. gondii</i> infection is associated with suicidal behavior in people with alcohol consumption.https://www.mdpi.com/2076-0817/10/6/734suicidal behaviorcross-sectional studyalcohol consumptionseroprevalenceepidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez |
spellingShingle |
Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez <i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption Pathogens suicidal behavior cross-sectional study alcohol consumption seroprevalence epidemiology |
author_facet |
Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez |
author_sort |
Cosme Alvarado-Esquivel |
title |
<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption |
title_short |
<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption |
title_full |
<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption |
title_fullStr |
<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption |
title_full_unstemmed |
<i>Toxoplasma gondii</i> Infection and Suicidal Behavior in People with Alcohol Consumption |
title_sort |
<i>toxoplasma gondii</i> infection and suicidal behavior in people with alcohol consumption |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2021-06-01 |
description |
We determined the association between <i>T. gondii</i> infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti-<i>T. gondii</i> IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Anti-<i>T. gondii</i> IgG antibodies were found in 34 of 224 (15.2%) individuals with suicidal ideation and in 118 (9.8%) of 1199 individuals without suicidal ideation (OR: 1.63; 95% CI: 1.08–2.47; <i>p</i> = 0.01). Seropositivity to <i>T. gondii</i> was associated with suicidal ideation in women (OR: 2.24; 95% CI: 1.33–3.78; <i>p</i> = 0.001) and in individuals aged ≤30 years (OR: 2.68; 95% CI: 1.22–5.87; <i>p</i> = 0.01) and >50 years (OR: 2.85; 95% CI: 1.19–6.77; <i>p</i> = 0.01). Anti-<i>T. gondii</i> IgG antibodies were found in 17 of 136 (12.5%) individuals with suicide attempts and in 135 (10.5%) of 1287 individuals without suicide attempts (OR: 1.21; 95% CI: 0.71–2.08; <i>p</i> = 0.47). Seroprevalence of <i>T. gondii</i> infection was associated with suicide attempts in women (OR: 1.88; 95% CI: 0.99–3.55; <i>p</i> = 0.04). No association between anti-<i>T. gondii</i> IgM and suicidal ideation or suicide attempts was found. Results suggest that <i>T. gondii</i> infection is associated with suicidal behavior in people with alcohol consumption. |
topic |
suicidal behavior cross-sectional study alcohol consumption seroprevalence epidemiology |
url |
https://www.mdpi.com/2076-0817/10/6/734 |
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