Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
Bibliographic Details
| Main Authors: |
Xiaohui Wang,
Xiang Lin,
Zihan Zheng,
Bingtai Lu,
Jun Wang,
Andy Hee-Meng Tan,
Meng Zhao,
Jia Tong Loh,
Sze Wai Ng,
Qian Chen,
Fan Xiao,
Enyu Huang,
King-Hung Ko,
Zhong Huang,
Jingyi Li,
Kin-Hang Kok,
Gen Lu,
Xiaohui Liu,
Kong-Peng Lam,
Wanli Liu,
Yuxia Zhang,
Kwok-Yung Yuen,
Tak Wah Mak,
Liwei Lu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22242-9
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