Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

Abstract Background DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome methylation and targeted mutation analysis of colorectal cancer (CRC)-rel...

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Bibliographic Details
Main Authors: Béla Molnár, Orsolya Galamb, Bálint Péterfia, Barnabás Wichmann, István Csabai, András Bodor, Alexandra Kalmár, Krisztina Andrea Szigeti, Barbara Kinga Barták, Zsófia Brigitta Nagy, Gábor Valcz, Árpád V. Patai, Péter Igaz, Zsolt Tulassay
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Adenoma
DNA methylation
Mutation
Methyl capture sequencing
TP53 signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12885-018-4609-x

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http://link.springer.com/article/10.1186/s12885-018-4609-x

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