Non-Neutralizing Antibodies Directed against HIV and Their Functions

Non-Neutralizing Antibodies Directed against HIV and Their Functions

B cells produce a plethora of anti-HIV antibodies (Abs) but only few of them exhibit neutralizing activity. This was long considered a profound limitation for the enforcement of humoral immune responses against HIV-1 infection, especially since these neutralizing Abs (nAbs) are extremely difficult t...

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Bibliographic Details
Main Authors: Luzia M. Mayr, Bin Su, Christiane Moog
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
HIV-1 infection
non-neutralizing antibodies
antibody functions
antibody-dependent cellular cytotoxicity
Fc-receptor-mediated inhibition
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01590/full

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