DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methylt...
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doaj-23389ee3c153479e9d01c48467e097f32020-11-25T03:18:27ZengMDPI AGCells2073-44092020-05-0191359135910.3390/cells9061359DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck CancersChameera Ekanayake Weeramange0Kai Dun Tang1Sarju Vasani2Julian Langton-Lockton3Liz Kenny4Chamindie Punyadeera5Queensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, AustraliaQueensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, AustraliaDepartment of Otolaryngology, Royal Brisbane and Women's Hospital, Queensland 4029, AustraliaMetro-North Sexual Health and HIV Service, Queensland 4000, AustraliaSchool of Medicine, The University of Queensland, Queensland 4006, AustraliaQueensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, AustraliaDisruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC.https://www.mdpi.com/2073-4409/9/6/1359head and neck cancerhuman papillomavirusDNA methylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chameera Ekanayake Weeramange Kai Dun Tang Sarju Vasani Julian Langton-Lockton Liz Kenny Chamindie Punyadeera |
spellingShingle |
Chameera Ekanayake Weeramange Kai Dun Tang Sarju Vasani Julian Langton-Lockton Liz Kenny Chamindie Punyadeera DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers Cells head and neck cancer human papillomavirus DNA methylation |
author_facet |
Chameera Ekanayake Weeramange Kai Dun Tang Sarju Vasani Julian Langton-Lockton Liz Kenny Chamindie Punyadeera |
author_sort |
Chameera Ekanayake Weeramange |
title |
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers |
title_short |
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers |
title_full |
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers |
title_fullStr |
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers |
title_full_unstemmed |
DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers |
title_sort |
dna methylation changes in human papillomavirus-driven head and neck cancers |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-05-01 |
description |
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC. |
topic |
head and neck cancer human papillomavirus DNA methylation |
url |
https://www.mdpi.com/2073-4409/9/6/1359 |
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