Neopterin: a Mediator of the Cellular Immune System
In this review, we will summarize our investigations on the potential biochemical, physiological, and pathophysiological effects of neopterin in the course of infection and inflammation. In a number of in v/'iro-studies wc could show that the pteridine compound neopterin manifested distinct bio...
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De Gruyter
2004-08-01
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Online Access: | https://doi.org/10.1515/pteridines.2004.15.3.107 |
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doaj-233ab76cf40a454792b3e5d612fa74282021-09-05T14:00:02ZengDe GruyterPteridines0933-48072195-47202004-08-0115310711210.1515/pteridines.2004.15.3.107Neopterin: a Mediator of the Cellular Immune SystemHoffmann Georg0Schobersberger Wolfgang1Institute for Leisure, Travel, and Alpine Medicine; University for Health Sciences, Medical Informatics and Technology, Innrain 98, 6020 Innsbruck, Austria, Phone: ++43-50-8648-3856, Fax: ++43-50-8648-673840Institute for Leisure, Travel, and Alpine Medicine; University for Health Sciences, Medical Informatics and Technology, AustriaIn this review, we will summarize our investigations on the potential biochemical, physiological, and pathophysiological effects of neopterin in the course of infection and inflammation. In a number of in v/'iro-studies wc could show that the pteridine compound neopterin manifested distinct biochemical properties via interfering with cellular redox mechanisms. Among the observed actions of neopterin are the stimulation of inducible nitric oxide synthase gene expression and nitric oxide release, the activation of the transcription factor nuclear factor-κΒ, the induction of apoptotic ccll death, the inhibition of erythropoietin synthesis and release, and the stimulation of tumor necrosis factor-α generation in different cell culture as well as organic models. By these means, neopterin may represent a part of the host-defence reactions. In addition, an excessive or continous release of neopterin due to a chronically activated cellular immune system may contribute to the deleterious events commonly observed in progressive infectious or inflammatory diseases. Our data are supported by the findings of a strong correlation between raised levels of neopterin and the severity and the outcome of these disorders.https://doi.org/10.1515/pteridines.2004.15.3.107neopterininfectioninflammationoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hoffmann Georg Schobersberger Wolfgang |
spellingShingle |
Hoffmann Georg Schobersberger Wolfgang Neopterin: a Mediator of the Cellular Immune System Pteridines neopterin infection inflammation oxidative stress |
author_facet |
Hoffmann Georg Schobersberger Wolfgang |
author_sort |
Hoffmann Georg |
title |
Neopterin: a Mediator of the Cellular Immune System |
title_short |
Neopterin: a Mediator of the Cellular Immune System |
title_full |
Neopterin: a Mediator of the Cellular Immune System |
title_fullStr |
Neopterin: a Mediator of the Cellular Immune System |
title_full_unstemmed |
Neopterin: a Mediator of the Cellular Immune System |
title_sort |
neopterin: a mediator of the cellular immune system |
publisher |
De Gruyter |
series |
Pteridines |
issn |
0933-4807 2195-4720 |
publishDate |
2004-08-01 |
description |
In this review, we will summarize our investigations on the potential biochemical, physiological, and pathophysiological effects of neopterin in the course of infection and inflammation. In a number of in v/'iro-studies wc could show that the pteridine compound neopterin manifested distinct biochemical properties via interfering with cellular redox mechanisms. Among the observed actions of neopterin are the stimulation of inducible nitric oxide synthase gene expression and nitric oxide release, the activation of the transcription factor nuclear factor-κΒ, the induction of apoptotic ccll death, the inhibition of erythropoietin synthesis and release, and the stimulation of tumor necrosis factor-α generation in different cell culture as well as organic models. By these means, neopterin may represent a part of the host-defence reactions. In addition, an excessive or continous release of neopterin due to a chronically activated cellular immune system may contribute to the deleterious events commonly observed in progressive infectious or inflammatory diseases. Our data are supported by the findings of a strong correlation between raised levels of neopterin and the severity and the outcome of these disorders. |
topic |
neopterin infection inflammation oxidative stress |
url |
https://doi.org/10.1515/pteridines.2004.15.3.107 |
work_keys_str_mv |
AT hoffmanngeorg neopterinamediatorofthecellularimmunesystem AT schobersbergerwolfgang neopterinamediatorofthecellularimmunesystem |
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1717812513593098240 |