Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to select...

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Main Authors: Qi Jia, Derek Sieburth
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22561-x
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spelling doaj-2344ed1897b64fa0bd9382bf5d084b8c2021-04-18T11:13:55ZengNature Publishing GroupNature Communications2041-17232021-04-0112112210.1038/s41467-021-22561-xMitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress responseQi Jia0Derek Sieburth1PIBBS program, Keck School of Medicine, University of Southern CaliforniaDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern CaliforniaMitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to selectively regulate neuropeptide secretion in C. elegans.https://doi.org/10.1038/s41467-021-22561-x
collection DOAJ
language English
format Article
sources DOAJ
author Qi Jia
Derek Sieburth
spellingShingle Qi Jia
Derek Sieburth
Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
Nature Communications
author_facet Qi Jia
Derek Sieburth
author_sort Qi Jia
title Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_short Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_full Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_fullStr Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_full_unstemmed Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_sort mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-04-01
description Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to selectively regulate neuropeptide secretion in C. elegans.
url https://doi.org/10.1038/s41467-021-22561-x
work_keys_str_mv AT qijia mitochondrialhydrogenperoxidepositivelyregulatesneuropeptidesecretionduringdietinducedactivationoftheoxidativestressresponse
AT dereksieburth mitochondrialhydrogenperoxidepositivelyregulatesneuropeptidesecretionduringdietinducedactivationoftheoxidativestressresponse
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