Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1
Heme oxygenase-1 (HO-1) is an inducible rate-controlling enzyme of heme catabolism. The cytoprotective function of HO-1 activity has been verified in multiple studies, and together with its by-products is considered a key component of the cellular stress response. The transcriptional induction of HO...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-01-01
|
Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00459/full |
id |
doaj-2347cbf16a844d1589e7ac15bcc682a1 |
---|---|
record_format |
Article |
spelling |
doaj-2347cbf16a844d1589e7ac15bcc682a12020-11-24T22:21:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-01-01810.3389/fncel.2014.00459110665Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1Marialuara eAmadio0Giovanni eScapagnini1Sergio eDavinelli2Vittorio eCalabrese3Stefano eGovoni4Alessia ePascale5University of PaviaUniversity of MoliseUniversity of MoliseUniversity of CataniaUniversity of PaviaUniversity of PaviaHeme oxygenase-1 (HO-1) is an inducible rate-controlling enzyme of heme catabolism. The cytoprotective function of HO-1 activity has been verified in multiple studies, and together with its by-products is considered a key component of the cellular stress response. The transcriptional induction of HO-1 has been largely studied in response to multiple forms of stressful stimuli but our understanding of HO-1 post-transcriptional control mechanisms in neuronal cells is currently lacking. In the present report we show the involvement of the RNA-binding proteins ELAV in the regulation of HO-1 gene expression. Our study demonstrates a specific binding between HO-1 mRNA and ELAV proteins in a human neuroblastoma cell line treated with hemin. Clarifying the induction of HO-1 expression at post-transcriptional level may open therapeutic perspectives for treatments associated with the modulation of HO-1 expression.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00459/fullHeme Oxygenase-1HeminPost-tranSH-SY5Y cellsELAV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marialuara eAmadio Giovanni eScapagnini Sergio eDavinelli Vittorio eCalabrese Stefano eGovoni Alessia ePascale |
spellingShingle |
Marialuara eAmadio Giovanni eScapagnini Sergio eDavinelli Vittorio eCalabrese Stefano eGovoni Alessia ePascale Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 Frontiers in Cellular Neuroscience Heme Oxygenase-1 Hemin Post-tran SH-SY5Y cells ELAV |
author_facet |
Marialuara eAmadio Giovanni eScapagnini Sergio eDavinelli Vittorio eCalabrese Stefano eGovoni Alessia ePascale |
author_sort |
Marialuara eAmadio |
title |
Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 |
title_short |
Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 |
title_full |
Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 |
title_fullStr |
Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 |
title_full_unstemmed |
Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 |
title_sort |
involvement of elav rna-binding proteins in the post-transcriptional regulation of ho-1 |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2015-01-01 |
description |
Heme oxygenase-1 (HO-1) is an inducible rate-controlling enzyme of heme catabolism. The cytoprotective function of HO-1 activity has been verified in multiple studies, and together with its by-products is considered a key component of the cellular stress response. The transcriptional induction of HO-1 has been largely studied in response to multiple forms of stressful stimuli but our understanding of HO-1 post-transcriptional control mechanisms in neuronal cells is currently lacking. In the present report we show the involvement of the RNA-binding proteins ELAV in the regulation of HO-1 gene expression. Our study demonstrates a specific binding between HO-1 mRNA and ELAV proteins in a human neuroblastoma cell line treated with hemin. Clarifying the induction of HO-1 expression at post-transcriptional level may open therapeutic perspectives for treatments associated with the modulation of HO-1 expression. |
topic |
Heme Oxygenase-1 Hemin Post-tran SH-SY5Y cells ELAV |
url |
http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00459/full |
work_keys_str_mv |
AT marialuaraeamadio involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 AT giovanniescapagnini involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 AT sergioedavinelli involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 AT vittorioecalabrese involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 AT stefanoegovoni involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 AT alessiaepascale involvementofelavrnabindingproteinsintheposttranscriptionalregulationofho1 |
_version_ |
1725772571344896000 |