Calcium citrate improves the epithelial-to-mesenchymal transition induced by acidosis in proximal tubular cells

Calcium citrate improves the epithelial-to-mesenchymal transition induced by acidosis in proximal tubular cells

INTRODUCTION: Epithelial-to-mesenchymal transition (EMT) is a key event in renal fibrosis. The aims of the study were to evaluate acidosis induced EMT, transforming-growth-factor (TGF) β1 role and citrate effect on it. METHODS: HK2 cells (ATCC 2290) were cultured in DMEM/HAM F12 medium, pH 7.4. At 8...

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Bibliographic Details
Main Authors: Maria José Rodriguez Cabalgante, Liliana Gadola, Leonella Luzardo, María Márquez, José Boggia, Mirian Aparecida Boim
Format: Article
Language:English
Published: Sociedade Brasileira de Nefrologia 2012-12-01
Series:Brazilian Journal of Nephrology
Subjects:
acidose
citratos
epitélio
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000400006&lng=en&tlng=en

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