Alterations of plasma lysophosphatidylcholine species in obesity and weight loss.
Obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lip...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4207804?pdf=render |
id |
doaj-234a92acf0344899a8999b321d4f5594 |
---|---|
record_format |
Article |
spelling |
doaj-234a92acf0344899a8999b321d4f55942020-11-25T01:18:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11134810.1371/journal.pone.0111348Alterations of plasma lysophosphatidylcholine species in obesity and weight loss.Susanne HeimerlMarcus FischerAndrea BaesslerGerhard LiebischAlexander SigruenerStefan WallnerGerd SchmitzObesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lipid species in this syndrome and existing data are contradictive.In this study, we quantified plasma lipid species by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in obese subjects before and after 3 month weight loss as well as in a control group.The comparison of obese subjects with control subjects before weight loss revealed significantly lower lysophosphatidylcholine (LPC) concentrations in obesity. LPC concentrations did not significantly increase during the observed period in the weight loss group. Analysis of LPC species revealed a decrease of most species in obesity and negative correlations with C-reactive protein (CRP) and body mass index (BMI). Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio.Our findings contribute to the contradictive discussion of the role of LPC in obesity and related chronic inflammation strongly supporting pre-existing data in the literature that show a decrease of LPC species in plasma of obese and a potentially anti-inflammatory role in these subjects.http://europepmc.org/articles/PMC4207804?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susanne Heimerl Marcus Fischer Andrea Baessler Gerhard Liebisch Alexander Sigruener Stefan Wallner Gerd Schmitz |
spellingShingle |
Susanne Heimerl Marcus Fischer Andrea Baessler Gerhard Liebisch Alexander Sigruener Stefan Wallner Gerd Schmitz Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. PLoS ONE |
author_facet |
Susanne Heimerl Marcus Fischer Andrea Baessler Gerhard Liebisch Alexander Sigruener Stefan Wallner Gerd Schmitz |
author_sort |
Susanne Heimerl |
title |
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
title_short |
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
title_full |
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
title_fullStr |
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
title_full_unstemmed |
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
title_sort |
alterations of plasma lysophosphatidylcholine species in obesity and weight loss. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lipid species in this syndrome and existing data are contradictive.In this study, we quantified plasma lipid species by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in obese subjects before and after 3 month weight loss as well as in a control group.The comparison of obese subjects with control subjects before weight loss revealed significantly lower lysophosphatidylcholine (LPC) concentrations in obesity. LPC concentrations did not significantly increase during the observed period in the weight loss group. Analysis of LPC species revealed a decrease of most species in obesity and negative correlations with C-reactive protein (CRP) and body mass index (BMI). Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio.Our findings contribute to the contradictive discussion of the role of LPC in obesity and related chronic inflammation strongly supporting pre-existing data in the literature that show a decrease of LPC species in plasma of obese and a potentially anti-inflammatory role in these subjects. |
url |
http://europepmc.org/articles/PMC4207804?pdf=render |
work_keys_str_mv |
AT susanneheimerl alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT marcusfischer alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT andreabaessler alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT gerhardliebisch alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT alexandersigruener alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT stefanwallner alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss AT gerdschmitz alterationsofplasmalysophosphatidylcholinespeciesinobesityandweightloss |
_version_ |
1725140542407311360 |