Inulin and Its Application in Drug Delivery
Inulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. Thi...
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doaj-234c3516bccc41fe93c72658a07e8f712021-09-26T00:55:23ZengMDPI AGPharmaceuticals1424-82472021-08-011485585510.3390/ph14090855Inulin and Its Application in Drug DeliveryFranklin Afinjuomo0Sadikalmahdi Abdella1Souha H. Youssef2Yunmei Song3Sanjay Garg4Pharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, AustraliaPharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, AustraliaPharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, AustraliaPharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, AustraliaPharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, AustraliaInulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems.https://www.mdpi.com/1424-8247/14/9/855inulindrug deliverynanoparticlesmicroparticleshydrogels |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Franklin Afinjuomo Sadikalmahdi Abdella Souha H. Youssef Yunmei Song Sanjay Garg |
spellingShingle |
Franklin Afinjuomo Sadikalmahdi Abdella Souha H. Youssef Yunmei Song Sanjay Garg Inulin and Its Application in Drug Delivery Pharmaceuticals inulin drug delivery nanoparticles microparticles hydrogels |
author_facet |
Franklin Afinjuomo Sadikalmahdi Abdella Souha H. Youssef Yunmei Song Sanjay Garg |
author_sort |
Franklin Afinjuomo |
title |
Inulin and Its Application in Drug Delivery |
title_short |
Inulin and Its Application in Drug Delivery |
title_full |
Inulin and Its Application in Drug Delivery |
title_fullStr |
Inulin and Its Application in Drug Delivery |
title_full_unstemmed |
Inulin and Its Application in Drug Delivery |
title_sort |
inulin and its application in drug delivery |
publisher |
MDPI AG |
series |
Pharmaceuticals |
issn |
1424-8247 |
publishDate |
2021-08-01 |
description |
Inulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems. |
topic |
inulin drug delivery nanoparticles microparticles hydrogels |
url |
https://www.mdpi.com/1424-8247/14/9/855 |
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