Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study
The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 pati...
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doaj-23568698392840ff9182d0e2e5338cbe2021-07-28T20:57:49ZrusNEW TERRA Publishing HouseTuberkulez i Bolezni Lëgkih2075-12302542-15062020-11-019810334010.21292/2075-1230-2020-98-10-33-401470Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative studyA. A. Vizel0D. A. Culver1I. Yu. Vizel2G. R. Shakirova3E. A. Bakunina4Kazan State Medical UniversityDepartment of Pulmonary Medicine, Respiratory Institute, Inflammation and Immunity Department, Lerner Research Institute, Cleveland ClinicKazan State Medical University; Central Tuberculosis Research InstituteKazan State Medical University; Republican Clinical Hospital, the Ministry of Health of Tatarstan RepublicThe Hospice Charity Fund «Vera»The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.https://www.tibl-journal.com/jour/article/view/1472sarcoidosisalpha-tocopherolfollow-uptreatmentcomparison |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. A. Vizel D. A. Culver I. Yu. Vizel G. R. Shakirova E. A. Bakunina |
spellingShingle |
A. A. Vizel D. A. Culver I. Yu. Vizel G. R. Shakirova E. A. Bakunina Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study Tuberkulez i Bolezni Lëgkih sarcoidosis alpha-tocopherol follow-up treatment comparison |
author_facet |
A. A. Vizel D. A. Culver I. Yu. Vizel G. R. Shakirova E. A. Bakunina |
author_sort |
A. A. Vizel |
title |
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
title_short |
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
title_full |
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
title_fullStr |
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
title_full_unstemmed |
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
title_sort |
assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study |
publisher |
NEW TERRA Publishing House |
series |
Tuberkulez i Bolezni Lëgkih |
issn |
2075-1230 2542-1506 |
publishDate |
2020-11-01 |
description |
The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment. |
topic |
sarcoidosis alpha-tocopherol follow-up treatment comparison |
url |
https://www.tibl-journal.com/jour/article/view/1472 |
work_keys_str_mv |
AT aavizel assessmentoftheeffectofalphatocopherolonthecourseofnewlydiagnosedpulmonarysarcoidosisacomparativestudy AT daculver assessmentoftheeffectofalphatocopherolonthecourseofnewlydiagnosedpulmonarysarcoidosisacomparativestudy AT iyuvizel assessmentoftheeffectofalphatocopherolonthecourseofnewlydiagnosedpulmonarysarcoidosisacomparativestudy AT grshakirova assessmentoftheeffectofalphatocopherolonthecourseofnewlydiagnosedpulmonarysarcoidosisacomparativestudy AT eabakunina assessmentoftheeffectofalphatocopherolonthecourseofnewlydiagnosedpulmonarysarcoidosisacomparativestudy |
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