Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer
Kyriaki Pistevou-Gompaki1, Apostolos Hatzitolios2, Nikos Eleftheriadis2, Evaggelos Boultoukas2, George Ntaios2, Ioannis Andronikidis2, Ioannis Tzitzikas11Department of Radiation Oncology; 2First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, GreeceIn...
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doaj-2360a96f24a54f94bfdca9aa7b182dd42020-11-24T22:37:20ZengDove Medical PressTherapeutics and Clinical Risk Management1176-63361178-203X2008-10-012008Issue 613591362Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancerKyriaki Pistevou-GompakiApostolos HatzitoliosNikos EleftheriadisEvaggelos BoultoukasGeorge Ntaioset alKyriaki Pistevou-Gompaki1, Apostolos Hatzitolios2, Nikos Eleftheriadis2, Evaggelos Boultoukas2, George Ntaios2, Ioannis Andronikidis2, Ioannis Tzitzikas11Department of Radiation Oncology; 2First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, GreeceIntroduction: Radiation treatment has been associated with radiation induced cardiotoxicity, especially with older, long-outdated, techniques. Such complications include pericarditis, myocardial fibrosis, valvular injury, ischemic heart disease, and myocardial infarction.Aim: To assess the effect of outdated breast radiation therapy (RT) – using a diagnostic CT scanner in the absence of a CT simulator – on cardiac function in women with stage II left breast cancer.Patients and Methods: Sixty-two women under 65 with stage II left breast cancer who received post-operative RT using a diagnostic computed tomography scanner were studied between 1997 and 2001. Participants underwent a clinical interview, ECG, and echocardiography before and 6 months and 5 years after RT.Results: There was no serious cardiotoxicity at 6 months and 5 years after radiotherapy. A 23% increase in hypertensive patients, and a slight decrease (2.3%) in ejection fraction was observed after 5 years, with 3 patients (5%) developing abnormalities. Two patients presented abnormal electrocardiographic findings within 6 months of RT.Conclusion: Our study showed that RT for left breast cancer was not associated with significant alteration in heart morbidity or mortality within 5 years of treatment, despite the lack of a simulator.Keywords: radiotherapy, breast cancer, cardiotoxicity, acute myocardial infraction, ischemic heart disease http://www.dovepress.com/evaluation-of-cardiotoxicity-five-years-after-2d-planned-non-simulated-a2331 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyriaki Pistevou-Gompaki Apostolos Hatzitolios Nikos Eleftheriadis Evaggelos Boultoukas George Ntaios et al |
spellingShingle |
Kyriaki Pistevou-Gompaki Apostolos Hatzitolios Nikos Eleftheriadis Evaggelos Boultoukas George Ntaios et al Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer Therapeutics and Clinical Risk Management |
author_facet |
Kyriaki Pistevou-Gompaki Apostolos Hatzitolios Nikos Eleftheriadis Evaggelos Boultoukas George Ntaios et al |
author_sort |
Kyriaki Pistevou-Gompaki |
title |
Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer |
title_short |
Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer |
title_full |
Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer |
title_fullStr |
Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer |
title_full_unstemmed |
Evaluation of cardiotoxicity five years after 2D planned, non-simulated, radiation therapy for left breast cancer |
title_sort |
evaluation of cardiotoxicity five years after 2d planned, non-simulated, radiation therapy for left breast cancer |
publisher |
Dove Medical Press |
series |
Therapeutics and Clinical Risk Management |
issn |
1176-6336 1178-203X |
publishDate |
2008-10-01 |
description |
Kyriaki Pistevou-Gompaki1, Apostolos Hatzitolios2, Nikos Eleftheriadis2, Evaggelos Boultoukas2, George Ntaios2, Ioannis Andronikidis2, Ioannis Tzitzikas11Department of Radiation Oncology; 2First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, GreeceIntroduction: Radiation treatment has been associated with radiation induced cardiotoxicity, especially with older, long-outdated, techniques. Such complications include pericarditis, myocardial fibrosis, valvular injury, ischemic heart disease, and myocardial infarction.Aim: To assess the effect of outdated breast radiation therapy (RT) – using a diagnostic CT scanner in the absence of a CT simulator – on cardiac function in women with stage II left breast cancer.Patients and Methods: Sixty-two women under 65 with stage II left breast cancer who received post-operative RT using a diagnostic computed tomography scanner were studied between 1997 and 2001. Participants underwent a clinical interview, ECG, and echocardiography before and 6 months and 5 years after RT.Results: There was no serious cardiotoxicity at 6 months and 5 years after radiotherapy. A 23% increase in hypertensive patients, and a slight decrease (2.3%) in ejection fraction was observed after 5 years, with 3 patients (5%) developing abnormalities. Two patients presented abnormal electrocardiographic findings within 6 months of RT.Conclusion: Our study showed that RT for left breast cancer was not associated with significant alteration in heart morbidity or mortality within 5 years of treatment, despite the lack of a simulator.Keywords: radiotherapy, breast cancer, cardiotoxicity, acute myocardial infraction, ischemic heart disease |
url |
http://www.dovepress.com/evaluation-of-cardiotoxicity-five-years-after-2d-planned-non-simulated-a2331 |
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