The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR)
Primary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct reni...
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Online Access: | https://doi.org/10.1177/1470320313519487 |
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doaj-236b2a60bd2241abb4f169657fcaac6f2021-05-02T19:50:09ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320313519487The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR)Piotr GlinickiWojciech JeskeLucyna Bednarek-PapierskaAleksandra KruszyńskaMałgorzata Gietka-CzernelElżbieta RosłonowskaJadwiga Słowińska-SrzednickaAnna Kasperlik-ZałuskaWojciech ZgliczyńskiPrimary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct renin concentration ratio (ADRR) could be similarly useful for screening patients suspected of PA. The study included 62 patients with indication for evaluation of the renin-angiotensin-aldosterone system and 35 healthy volunteers. In all participants we measured concentrations of serum aldosterone, plasma direct renin, and PRA after a night’s rest and again after walking for two hours. The concentrations of aldosterone, direct renin, and PRA were measured by isotopic methods (radioimmunoassay (RIA) / immunoradiometric assay (IRMA)). Correlations of ARR with ADRR in the supine position were r = 0.9162, r 2 = 0.8165 ( p < 0.01); and in the up-right position were r = 0.7765, r 2 = 0.9153 ( p < 0.01). The cut-off values of ARR and ADRR ≥ 100 presented highest specificity (99%) for the diagnosis of PA; however, quite acceptable specificity and sensitivity (> 80% and 100%, respectively) appeared for the ratios ≥ 30. We suggest that for practical and economic reasons ARR can be replaced by ADRR.https://doi.org/10.1177/1470320313519487 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński |
spellingShingle |
Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński |
author_sort |
Piotr Glinicki |
title |
The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
title_short |
The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
title_full |
The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
title_fullStr |
The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
title_full_unstemmed |
The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
title_sort |
ratios of aldosterone / plasma renin activity (arr) versus aldosterone / direct renin concentration (adrr) |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2015-12-01 |
description |
Primary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct renin concentration ratio (ADRR) could be similarly useful for screening patients suspected of PA. The study included 62 patients with indication for evaluation of the renin-angiotensin-aldosterone system and 35 healthy volunteers. In all participants we measured concentrations of serum aldosterone, plasma direct renin, and PRA after a night’s rest and again after walking for two hours. The concentrations of aldosterone, direct renin, and PRA were measured by isotopic methods (radioimmunoassay (RIA) / immunoradiometric assay (IRMA)). Correlations of ARR with ADRR in the supine position were r = 0.9162, r 2 = 0.8165 ( p < 0.01); and in the up-right position were r = 0.7765, r 2 = 0.9153 ( p < 0.01). The cut-off values of ARR and ADRR ≥ 100 presented highest specificity (99%) for the diagnosis of PA; however, quite acceptable specificity and sensitivity (> 80% and 100%, respectively) appeared for the ratios ≥ 30. We suggest that for practical and economic reasons ARR can be replaced by ADRR. |
url |
https://doi.org/10.1177/1470320313519487 |
work_keys_str_mv |
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