High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation
Abstract Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this increase is proportional to the aggressivene...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-02-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-19568-8 |
id |
doaj-236f961aaeed4316833c7b6131b30204 |
---|---|
record_format |
Article |
spelling |
doaj-236f961aaeed4316833c7b6131b302042020-12-08T05:21:14ZengNature Publishing GroupScientific Reports2045-23222018-02-018111210.1038/s41598-018-19568-8High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell ProliferationMassimiliano Ruscica0Margherita Botta1Nicola Ferri2Eleonora Giorgio3Chiara Macchi4Guido Franceschini5Paolo Magni6Laura Calabresi7Monica Gomaraschi8Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoDipartimento di Scienze del Farmaco, Università degli Studi di PadovaCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di MilanoAbstract Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this increase is proportional to the aggressiveness of the phenotype. Since high density lipoproteins (HDL) are known to exert antioxidant activities, their ability to reduce ROS levels and the consequent impact on cell proliferation was tested in normal and PCa cell lines. HDL significantly reduced basal and H2O2-induced oxidative stress in normal, androgen receptor (AR)-positive and AR-null PCa cell lines. AR, scavenger receptor BI and ATP binding cassette G1 transporter were not involved. In addition, HDL completely blunted H2O2-induced increase of cell proliferation, through their capacity to prevent the H2O2-induced shift of cell cycle distribution from G0/G1 towards G2/M phase. Synthetic HDL, made of the two main components of plasma-derived HDL (apoA-I and phosphatidylcholine) and which are under clinical development as anti-atherosclerotic agents, retained the ability of HDL to inhibit ROS production in PCa cells. Collectively, HDL antioxidant activity limits cell proliferation induced by ROS in AR-positive and AR-null PCa cell lines, thus supporting a possible role of HDL against PCa progression.https://doi.org/10.1038/s41598-018-19568-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Massimiliano Ruscica Margherita Botta Nicola Ferri Eleonora Giorgio Chiara Macchi Guido Franceschini Paolo Magni Laura Calabresi Monica Gomaraschi |
spellingShingle |
Massimiliano Ruscica Margherita Botta Nicola Ferri Eleonora Giorgio Chiara Macchi Guido Franceschini Paolo Magni Laura Calabresi Monica Gomaraschi High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation Scientific Reports |
author_facet |
Massimiliano Ruscica Margherita Botta Nicola Ferri Eleonora Giorgio Chiara Macchi Guido Franceschini Paolo Magni Laura Calabresi Monica Gomaraschi |
author_sort |
Massimiliano Ruscica |
title |
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation |
title_short |
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation |
title_full |
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation |
title_fullStr |
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation |
title_full_unstemmed |
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation |
title_sort |
high density lipoproteins inhibit oxidative stress-induced prostate cancer cell proliferation |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-02-01 |
description |
Abstract Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this increase is proportional to the aggressiveness of the phenotype. Since high density lipoproteins (HDL) are known to exert antioxidant activities, their ability to reduce ROS levels and the consequent impact on cell proliferation was tested in normal and PCa cell lines. HDL significantly reduced basal and H2O2-induced oxidative stress in normal, androgen receptor (AR)-positive and AR-null PCa cell lines. AR, scavenger receptor BI and ATP binding cassette G1 transporter were not involved. In addition, HDL completely blunted H2O2-induced increase of cell proliferation, through their capacity to prevent the H2O2-induced shift of cell cycle distribution from G0/G1 towards G2/M phase. Synthetic HDL, made of the two main components of plasma-derived HDL (apoA-I and phosphatidylcholine) and which are under clinical development as anti-atherosclerotic agents, retained the ability of HDL to inhibit ROS production in PCa cells. Collectively, HDL antioxidant activity limits cell proliferation induced by ROS in AR-positive and AR-null PCa cell lines, thus supporting a possible role of HDL against PCa progression. |
url |
https://doi.org/10.1038/s41598-018-19568-8 |
work_keys_str_mv |
AT massimilianoruscica highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT margheritabotta highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT nicolaferri highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT eleonoragiorgio highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT chiaramacchi highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT guidofranceschini highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT paolomagni highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT lauracalabresi highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation AT monicagomaraschi highdensitylipoproteinsinhibitoxidativestressinducedprostatecancercellproliferation |
_version_ |
1724391731527417856 |