rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility and benefits of providing highly chondroreparative agents, the cartilage-specific sex-determi...

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Bibliographic Details
Main Authors: Weikun Meng, Ana Rey-Rico, Mickaël Claudel, Gertrud Schmitt, Susanne Speicher-Mentges, Françoise Pons, Luc Lebeau, Jagadeesh K. Venkatesan, Magali Cucchiarini
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Nanomaterials
Subjects:
bone marrow-derived mesenchymal stromal cells
rAAV vectors
carbon dots
SOX9
TGF-β
cartilage repair
Online Access:https://www.mdpi.com/2079-4991/10/5/855

Internet

https://www.mdpi.com/2079-4991/10/5/855

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