Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life

Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life

Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later l...

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Main Authors: Minglan Li, Clare M. Reynolds, Stephanie A. Segovia, Clint Gray, Mark H. Vickers
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/437107
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spelling doaj-237b7561814940a19d569317a0a78b172020-11-24T23:19:38ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/437107437107Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later LifeMinglan Li0Clare M. Reynolds1Stephanie A. Segovia2Clint Gray3Mark H. Vickers4Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandNonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.http://dx.doi.org/10.1155/2015/437107
collection DOAJ
language English
format Article
sources DOAJ
author Minglan Li
Clare M. Reynolds
Stephanie A. Segovia
Clint Gray
Mark H. Vickers
spellingShingle Minglan Li
Clare M. Reynolds
Stephanie A. Segovia
Clint Gray
Mark H. Vickers
Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
BioMed Research International
author_facet Minglan Li
Clare M. Reynolds
Stephanie A. Segovia
Clint Gray
Mark H. Vickers
author_sort Minglan Li
title Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
title_short Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
title_full Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
title_fullStr Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
title_full_unstemmed Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life
title_sort developmental programming of nonalcoholic fatty liver disease: the effect of early life nutrition on susceptibility and disease severity in later life
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.
url http://dx.doi.org/10.1155/2015/437107
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