Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

<p>Abstract</p> <p>Background</p> <p>RC-101, a cationic peptide retrocyclin analog, has <it>in vitro </it>activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation...

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Bibliographic Details
Main Authors: Conrads Thomas P, Hood Brian L, Bunge Katherine E, Sassi Alexandra B, Cole Alexander M, Gupta Phalguni, Rohan Lisa C
Format: Article
Language:English
Published: BMC 2011-07-01
Series:AIDS Research and Therapy
Online Access:http://www.aidsrestherapy.com/content/8/1/27

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