| Summary: | Aim: Liver cirrhosis isa process characterized by fibrosis and normal liver structure is replaced with diffuse nodular structure. Different laboratory values are used for diagnosis and prognosis of liver cirrhosis. To determine platelet and mean platelet volume levels of patients with liver cirrhosis and to find out if platelet or mean platelet volume levels have changed according to Child-Pugh classification or the etiology of cirrhosis.Methods: A total of 201 patients with cirrhosis who have been followed by of an education and research hospital internal medicine out-patient clinic between the years of 2006 and 2013, were included. Platelet count <150,000 / µL was accepted as thrombocytopenia. Individuals with diseases that can cause thrombocytopenia, patients using drugs that can cause thrombocytopenia and who has pseudothrombocytopenia were excluded from the study.Results: The number percantage ratios of patients according to underlying etiology for chronic liver disease were as follows Group 1 (alcoholic liver disease) with rate of % 16.9, Group 2 (hepatitis – B) with rate of % 25.4, Group 3 (hepatitis – C) with rate of % 23.4, Group 4 (cryptogenic) with rate of % 34.3.Average platelet value in the Group 1 was 130.2 ± 74 x 103/ µL, Group 2 was 104.8 ± 56.8 x 103/ µL, Group 3 was 100.6 ± 44.2 x 103/ µL, Group 4 was 104,1 ± 48.7 x 103/ µL;average platelet value in the control group (Group 5) was 247.7 ± 58.7 x 103 / µL. Average mean platelet volume values in the Group 1 was 9.19 ± 1.32 fL, Group2 was 9.21 ± 1.57 fL, Group 3 was 8.67 ± 1.25 fL, Group 4 was 8.85 ± 1.21 fL; average mean platelet volume value in the Group 5 was 8.05 ± 1 fL. Conclusion: In this study, platelet levels of the cirrhotic patients were lower than the control group’s platelet levels; MPV levels of the patients with cirrhosis were higher than the control group’s mean platelet volume levels. Platelet and MPV values were not different according to Child-Pugh stage or cirrhosis etiology. Therefore, more and larger scaled studies are needed to clarify conflicting conclusions about the impact of platelet number and MPV on chronic liver inflammation.
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