Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus

Canine distemper is a highly contagious viral disease caused by the canine distemper virus (CDV), which is a member of the Morbillivirus genus, Paramyxoviridae family. Animals that most commonly suffer from this disease belong to the Canidae family; however, the spectrum of natural hosts for CDV als...

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Main Authors:	Otávio Valério Carvalho, Clarisse Vieira Botelho, Caroline Gracielle Torres Ferreira, Paulo Oldemar Scherer, Jamária Adriana Pinheiro Soares-Martins, Márcia Rogéria Almeida, Abelardo Silva Júnior
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Advances in Virology
Online Access:	http://dx.doi.org/10.1155/2012/163860

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spelling	doaj-238bb5c81d864a45a21609e2a95cbe962021-07-02T04:41:06ZengHindawi LimitedAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/163860163860Immunopathogenic and Neurological Mechanisms of Canine Distemper VirusOtávio Valério Carvalho0Clarisse Vieira Botelho1Caroline Gracielle Torres Ferreira2Paulo Oldemar Scherer3Jamária Adriana Pinheiro Soares-Martins4Márcia Rogéria Almeida5Abelardo Silva Júnior6Instituto de Veterinária (IV), Universidade Federal Rural do Rio de Janeiro, Rodovia BR 465, km 7, 23890-000 Seropédica, RJ, BrazilLaboratório de Virologia Molecular Animal (LVMA), Departamento de Veterinária, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-000 Viçosa, MG, BrazilLaboratório de Virologia Molecular Animal (LVMA), Departamento de Veterinária, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-000 Viçosa, MG, BrazilInstituto de Veterinária (IV), Universidade Federal Rural do Rio de Janeiro, Rodovia BR 465, km 7, 23890-000 Seropédica, RJ, BrazilDepartment of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USALaboratório de Virologia Molecular Animal (LVMA), Departamento de Veterinária, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-000 Viçosa, MG, BrazilLaboratório de Virologia Molecular Animal (LVMA), Departamento de Veterinária, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-000 Viçosa, MG, BrazilCanine distemper is a highly contagious viral disease caused by the canine distemper virus (CDV), which is a member of the Morbillivirus genus, Paramyxoviridae family. Animals that most commonly suffer from this disease belong to the Canidae family; however, the spectrum of natural hosts for CDV also includes several other families of the order Carnivora. The infectious disease presents worldwide distribution and maintains a high incidence and high levels of lethality, despite the availability of effective vaccines, and no specific treatment. CDV infection in dogs is characterized by the presentation of systemic and/or neurological courses, and viral persistence in some organs, including the central nervous system (CNS) and lymphoid tissues. An elucidation of the pathogenic mechanisms involved in canine distemper disease will lead to a better understanding of the injuries and clinical manifestations caused by CDV. Ultimately, further insight about this disease will enable the improvement of diagnostic methods as well as therapeutic studies.http://dx.doi.org/10.1155/2012/163860
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Otávio Valério Carvalho Clarisse Vieira Botelho Caroline Gracielle Torres Ferreira Paulo Oldemar Scherer Jamária Adriana Pinheiro Soares-Martins Márcia Rogéria Almeida Abelardo Silva Júnior
spellingShingle	Otávio Valério Carvalho Clarisse Vieira Botelho Caroline Gracielle Torres Ferreira Paulo Oldemar Scherer Jamária Adriana Pinheiro Soares-Martins Márcia Rogéria Almeida Abelardo Silva Júnior Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus Advances in Virology
author_facet	Otávio Valério Carvalho Clarisse Vieira Botelho Caroline Gracielle Torres Ferreira Paulo Oldemar Scherer Jamária Adriana Pinheiro Soares-Martins Márcia Rogéria Almeida Abelardo Silva Júnior
author_sort	Otávio Valério Carvalho
title	Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
title_short	Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
title_full	Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
title_fullStr	Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
title_full_unstemmed	Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
title_sort	immunopathogenic and neurological mechanisms of canine distemper virus
publisher	Hindawi Limited
series	Advances in Virology
issn	1687-8639 1687-8647
publishDate	2012-01-01
description	Canine distemper is a highly contagious viral disease caused by the canine distemper virus (CDV), which is a member of the Morbillivirus genus, Paramyxoviridae family. Animals that most commonly suffer from this disease belong to the Canidae family; however, the spectrum of natural hosts for CDV also includes several other families of the order Carnivora. The infectious disease presents worldwide distribution and maintains a high incidence and high levels of lethality, despite the availability of effective vaccines, and no specific treatment. CDV infection in dogs is characterized by the presentation of systemic and/or neurological courses, and viral persistence in some organs, including the central nervous system (CNS) and lymphoid tissues. An elucidation of the pathogenic mechanisms involved in canine distemper disease will lead to a better understanding of the injuries and clinical manifestations caused by CDV. Ultimately, further insight about this disease will enable the improvement of diagnostic methods as well as therapeutic studies.
url	http://dx.doi.org/10.1155/2012/163860
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Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus

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