Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases
Background: Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Met...
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Bioscientifica
2019-02-01
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doaj-23937dacb69a4a55a4fb38a0c74d4e172020-11-25T00:52:54ZengBioscientificaEndocrine Connections2049-36142049-36142019-02-0183173181https://doi.org/10.1530/EC-18-0370Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseasesWeiwei He0Bin Wang1Kaida Mu2Jing Zhang3Yanping Yang4Wei Yao5Sheli Li6Jin-an ZhangDepartment of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, ChinaDepartment of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, ChinaDepartment of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, ChinaBackground: Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Methods: Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput geneotyping in 843 patients with AITDs (516 Graves’ disease (GD) and 327 Hashimoto’s thyroiditis (HT)) and 677 healthy controls in Chinese Han population. Results: Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206. Conclusion: Our study, for the first time, showed the significant association of the IL27 gene SNPs with AITD.https://ec.bioscientifica.com/view/journals/ec/8/3/EC-18-0370.xmlinterleukin-27single-nucleotide polymorphismautoimmune thyroid diseasessusceptibility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weiwei He Bin Wang Kaida Mu Jing Zhang Yanping Yang Wei Yao Sheli Li Jin-an Zhang |
spellingShingle |
Weiwei He Bin Wang Kaida Mu Jing Zhang Yanping Yang Wei Yao Sheli Li Jin-an Zhang Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases Endocrine Connections interleukin-27 single-nucleotide polymorphism autoimmune thyroid diseases susceptibility |
author_facet |
Weiwei He Bin Wang Kaida Mu Jing Zhang Yanping Yang Wei Yao Sheli Li Jin-an Zhang |
author_sort |
Weiwei He |
title |
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases |
title_short |
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases |
title_full |
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases |
title_fullStr |
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases |
title_full_unstemmed |
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases |
title_sort |
association of single-nucleotide polymorphisms in the il27 gene with autoimmune thyroid diseases |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2019-02-01 |
description |
Background: Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs).
Methods: Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput geneotyping in 843 patients with AITDs (516 Graves’ disease (GD) and 327 Hashimoto’s thyroiditis (HT)) and 677 healthy controls in Chinese Han population.
Results: Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
Conclusion: Our study, for the first time, showed the significant association of the IL27
gene SNPs with AITD. |
topic |
interleukin-27 single-nucleotide polymorphism autoimmune thyroid diseases susceptibility |
url |
https://ec.bioscientifica.com/view/journals/ec/8/3/EC-18-0370.xml |
work_keys_str_mv |
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