Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study
Although abnormal auditory sensitivity is the most common sensory impairment associated with autism spectrum disorder (ASD), the neurophysiological mechanisms remain unknown. In previous studies, we reported that this abnormal sensitivity in patients with ASD is associated with delayed and prolonged...
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Frontiers Media S.A.
2017-09-01
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00446/full |
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doaj-239d488f7aaf48c29725ea207d3f30a8 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junko Matsuzaki Junko Matsuzaki Junko Matsuzaki Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Hisato Sugata Ryuzo Hanaie Ryuzo Hanaie Fumiyo Nagatani Tomoka Yamamoto Masaya Tachibana Masaya Tachibana Masaya Tachibana Koji Tominaga Koji Tominaga Masayuki Hirata Masayuki Hirata Ikuko Mohri Ikuko Mohri Ikuko Mohri Masako Taniike Masako Taniike Masako Taniike |
spellingShingle |
Junko Matsuzaki Junko Matsuzaki Junko Matsuzaki Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Hisato Sugata Ryuzo Hanaie Ryuzo Hanaie Fumiyo Nagatani Tomoka Yamamoto Masaya Tachibana Masaya Tachibana Masaya Tachibana Koji Tominaga Koji Tominaga Masayuki Hirata Masayuki Hirata Ikuko Mohri Ikuko Mohri Ikuko Mohri Masako Taniike Masako Taniike Masako Taniike Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study Frontiers in Human Neuroscience autism spectrum disorders (ASD) abnormal auditory sensitivity mismatch fields magnetoencephalography (MEG) oddball paradigm |
author_facet |
Junko Matsuzaki Junko Matsuzaki Junko Matsuzaki Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Hisato Sugata Ryuzo Hanaie Ryuzo Hanaie Fumiyo Nagatani Tomoka Yamamoto Masaya Tachibana Masaya Tachibana Masaya Tachibana Koji Tominaga Koji Tominaga Masayuki Hirata Masayuki Hirata Ikuko Mohri Ikuko Mohri Ikuko Mohri Masako Taniike Masako Taniike Masako Taniike |
author_sort |
Junko Matsuzaki |
title |
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study |
title_short |
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study |
title_full |
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study |
title_fullStr |
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study |
title_full_unstemmed |
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study |
title_sort |
delayed mismatch field latencies in autism spectrum disorder with abnormal auditory sensitivity: a magnetoencephalographic study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2017-09-01 |
description |
Although abnormal auditory sensitivity is the most common sensory impairment associated with autism spectrum disorder (ASD), the neurophysiological mechanisms remain unknown. In previous studies, we reported that this abnormal sensitivity in patients with ASD is associated with delayed and prolonged responses in the auditory cortex. In the present study, we investigated alterations in residual M100 and MMFs in children with ASD who experience abnormal auditory sensitivity. We used magnetoencephalography (MEG) to measure MMF elicited by an auditory oddball paradigm (standard tones: 300 Hz, deviant tones: 700 Hz) in 20 boys with ASD (11 with abnormal auditory sensitivity: mean age, 9.62 ± 1.82 years, 9 without: mean age, 9.07 ± 1.31 years) and 13 typically developing boys (mean age, 9.45 ± 1.51 years). We found that temporal and frontal residual M100/MMF latencies were significantly longer only in children with ASD who have abnormal auditory sensitivity. In addition, prolonged residual M100/MMF latencies were correlated with the severity of abnormal auditory sensitivity in temporal and frontal areas of both hemispheres. Therefore, our findings suggest that children with ASD and abnormal auditory sensitivity may have atypical neural networks in the primary auditory area, as well as in brain areas associated with attention switching and inhibitory control processing. This is the first report of an MEG study demonstrating altered MMFs to an auditory oddball paradigm in patients with ASD and abnormal auditory sensitivity. These findings contribute to knowledge of the mechanisms for abnormal auditory sensitivity in ASD, and may therefore facilitate development of novel clinical interventions. |
topic |
autism spectrum disorders (ASD) abnormal auditory sensitivity mismatch fields magnetoencephalography (MEG) oddball paradigm |
url |
http://journal.frontiersin.org/article/10.3389/fnhum.2017.00446/full |
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doaj-239d488f7aaf48c29725ea207d3f30a82020-11-25T02:19:28ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-09-011110.3389/fnhum.2017.00446259353Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic StudyJunko Matsuzaki0Junko Matsuzaki1Junko Matsuzaki2Kuriko Kagitani-Shimono3Kuriko Kagitani-Shimono4Kuriko Kagitani-Shimono5Hisato Sugata6Ryuzo Hanaie7Ryuzo Hanaie8Fumiyo Nagatani9Tomoka Yamamoto10Masaya Tachibana11Masaya Tachibana12Masaya Tachibana13Koji Tominaga14Koji Tominaga15Masayuki Hirata16Masayuki Hirata17Ikuko Mohri18Ikuko Mohri19Ikuko Mohri20Masako Taniike21Masako Taniike22Masako Taniike23Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Neurosurgery, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Neurosurgery, Osaka University Graduate School of MedicineOsaka, JapanEndowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka UniversityOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University Graduate School of MedicineOsaka, JapanDepartment of Pediatrics, Osaka University Graduate School of MedicineOsaka, JapanAlthough abnormal auditory sensitivity is the most common sensory impairment associated with autism spectrum disorder (ASD), the neurophysiological mechanisms remain unknown. In previous studies, we reported that this abnormal sensitivity in patients with ASD is associated with delayed and prolonged responses in the auditory cortex. In the present study, we investigated alterations in residual M100 and MMFs in children with ASD who experience abnormal auditory sensitivity. We used magnetoencephalography (MEG) to measure MMF elicited by an auditory oddball paradigm (standard tones: 300 Hz, deviant tones: 700 Hz) in 20 boys with ASD (11 with abnormal auditory sensitivity: mean age, 9.62 ± 1.82 years, 9 without: mean age, 9.07 ± 1.31 years) and 13 typically developing boys (mean age, 9.45 ± 1.51 years). We found that temporal and frontal residual M100/MMF latencies were significantly longer only in children with ASD who have abnormal auditory sensitivity. In addition, prolonged residual M100/MMF latencies were correlated with the severity of abnormal auditory sensitivity in temporal and frontal areas of both hemispheres. Therefore, our findings suggest that children with ASD and abnormal auditory sensitivity may have atypical neural networks in the primary auditory area, as well as in brain areas associated with attention switching and inhibitory control processing. This is the first report of an MEG study demonstrating altered MMFs to an auditory oddball paradigm in patients with ASD and abnormal auditory sensitivity. These findings contribute to knowledge of the mechanisms for abnormal auditory sensitivity in ASD, and may therefore facilitate development of novel clinical interventions.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00446/fullautism spectrum disorders (ASD)abnormal auditory sensitivitymismatch fieldsmagnetoencephalography (MEG)oddball paradigm |