Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.

The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3' untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in DM1. Expanded CUG tracts form both nuclear an...

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Bibliographic Details
Main Authors: Warunee Dansithong, Cordula M Wolf, Partha Sarkar, Sharan Paul, Andy Chiang, Ian Holt, Glenn E Morris, Dorothy Branco, Megan C Sherwood, Lucio Comai, Charles I Berul, Sita Reddy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2597774?pdf=render

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