A systematic review of sex differences in the placebo and the nocebo effect
Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review investigated whether there are systematic sex di...
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doaj-23a951930cb74ee4b2145c0f0ddeeeb62020-11-24T22:48:12ZengDove Medical PressJournal of Pain Research1178-70902017-07-01Volume 101831183934032A systematic review of sex differences in the placebo and the nocebo effectVambheim SMFlaten MASara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review investigated whether there are systematic sex differences in the placebo and the nocebo effect. Methods: A literature search was conducted in multiple electronic databases. Studies were included if the study compared a group or condition where a placebo was administered to a natural history group or similar cohort. Results: Eighteen studies were identified – 12 on placebo effects and 6 on nocebo effects. Chi-square tests revealed that 1) males responded more strongly to placebo treatment, and females responded more strongly to nocebo treatment, and 2) males responded with larger placebo effects induced by verbal information, and females responded with larger nocebo effects induced by conditioning procedures. Conclusion: This review indicates that there are sex differences in the placebo and nocebo effects, probably caused by sex differences in stress, anxiety, and the endogenous opioid system. Keywords: placebo response, nocebo response, placebo analgesia, nocebo hyperalgesia, sex differenceshttps://www.dovepress.com/a-systematic-review-of-sex-differences-in-the-placebo-and-the-nocebo-e-peer-reviewed-article-JPRplacebo effectnocebo effectplacebo responsenocebo responseplacebo analgesianocebo hyperalgesiasex differences |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vambheim SM Flaten MA |
spellingShingle |
Vambheim SM Flaten MA A systematic review of sex differences in the placebo and the nocebo effect Journal of Pain Research placebo effect nocebo effect placebo response nocebo response placebo analgesia nocebo hyperalgesia sex differences |
author_facet |
Vambheim SM Flaten MA |
author_sort |
Vambheim SM |
title |
A systematic review of sex differences in the placebo and the nocebo effect |
title_short |
A systematic review of sex differences in the placebo and the nocebo effect |
title_full |
A systematic review of sex differences in the placebo and the nocebo effect |
title_fullStr |
A systematic review of sex differences in the placebo and the nocebo effect |
title_full_unstemmed |
A systematic review of sex differences in the placebo and the nocebo effect |
title_sort |
systematic review of sex differences in the placebo and the nocebo effect |
publisher |
Dove Medical Press |
series |
Journal of Pain Research |
issn |
1178-7090 |
publishDate |
2017-07-01 |
description |
Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review investigated whether there are systematic sex differences in the placebo and the nocebo effect. Methods: A literature search was conducted in multiple electronic databases. Studies were included if the study compared a group or condition where a placebo was administered to a natural history group or similar cohort. Results: Eighteen studies were identified – 12 on placebo effects and 6 on nocebo effects. Chi-square tests revealed that 1) males responded more strongly to placebo treatment, and females responded more strongly to nocebo treatment, and 2) males responded with larger placebo effects induced by verbal information, and females responded with larger nocebo effects induced by conditioning procedures. Conclusion: This review indicates that there are sex differences in the placebo and nocebo effects, probably caused by sex differences in stress, anxiety, and the endogenous opioid system. Keywords: placebo response, nocebo response, placebo analgesia, nocebo hyperalgesia, sex differences |
topic |
placebo effect nocebo effect placebo response nocebo response placebo analgesia nocebo hyperalgesia sex differences |
url |
https://www.dovepress.com/a-systematic-review-of-sex-differences-in-the-placebo-and-the-nocebo-e-peer-reviewed-article-JPR |
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