The association of lumican polymorphisms and high myopia in a Southern Chinese population
AIM: To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population. METHODS: The study comprised of 95 high myopia patients with a spherical equivalent ≤−6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging fro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2017-10-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2017/10/20171006.pdf |
| Summary: | AIM: To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population.
METHODS: The study comprised of 95 high myopia patients with a spherical equivalent ≤−6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from −0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg disequilibrium. Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher’s exact test.
RESULTS: We identified 3 SNPs of the LUM gene: LUM c.32 (rs577456426), LUM c.507 (rs17853500) and LUM c.849 (rs181915277). Among the three SNPs, the genotype and allele frequencies of rs17853500 showed a significant difference between patients and control subjects (P<0.05). However, there were no significant differences in rs181915277 and rs577456426 between the two groups (P>0.05).
CONCLUSION: LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population. |
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| ISSN: | 2222-3959 2227-4898 |