Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS

Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS

The neuroprotective evaluation of ligustrazine derivatives has become a research focus all over the world. A novel ligustrazine derivative, (3,5,6-Trimethylpyrazin-2-yl)methyl(E)-3-(4-((3,5,6-trimethylpyrazin-2-l)methoxy)phenyl)acrylate (T-CA), has shown protective effects against CoCl2-induced neur...

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Bibliographic Details
Main Authors: Xinyu Zhang, Rui Zhao, Meng Chen, Tao Ma, Gaorong Wu, Nannan Xue, Guoliang Li, Hui Wang, Kang Fang, Wenxi Zhang, Penglong Wang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
liquid chromatography-electrospray ionizationion trap mass spectrometry (LC/LTQ-Orbitrap MS)
fragmentation regularities
ligustrazine derivative metabolites
neuroprotective activity
Online Access:http://www.mdpi.com/1420-3049/23/5/1154

Internet

http://www.mdpi.com/1420-3049/23/5/1154

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