Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation
After allogeneic hematopoietic stem cell transplantation (allo-HSCT), acute leukemia relapse is common, and asymmetric bone marrow recurrence hasn't been reported. Because the anatomical distribution of acute leukemia clones in the bone marrow after allo-HSCT is presumed to be diffuse, bone mar...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.626018/full |
id |
doaj-23b89d9f4d3e4840afa1908fa529653b |
---|---|
record_format |
Article |
spelling |
doaj-23b89d9f4d3e4840afa1908fa529653b2021-03-04T08:20:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.626018626018Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell TransplantationHan Yan0Zhenyang Zhou1Zhenyang Zhou2Yingying Wu3Zhaodong Zhong4Yong You5Junxia Yao6Wanxin Chen7Linghui Xia8Xiaotian Xia9Wei Shi10Wei Shi11Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaFred Hutchinson Cancer Research Center, Seattle, WA, United StatesAfter allogeneic hematopoietic stem cell transplantation (allo-HSCT), acute leukemia relapse is common, and asymmetric bone marrow recurrence hasn't been reported. Because the anatomical distribution of acute leukemia clones in the bone marrow after allo-HSCT is presumed to be diffuse, bone marrow aspirations are performed in single site. The first case was a 20-year-old man who was diagnosed with acute myelomonocytic leukemia and received haploidentical allo-HSCT. Routine bone marrow biopsy of his left posterior iliac bone marrow showed 52% leukemia blasts, while the right side had 0% blasts 10 days later. The second case was a 23-year-old woman who was diagnosed with acute B lymphoblastic leukemia and received HLA-identical sibling allo-HSCT. Although 62% of blasts were found in her left iliac marrow on day +122, 0% of blasts were found on a sample obtained from the right iliac crest on day +128. Bilateral iliac bone marrow pathology and whole-body 18F-FDG PET/CT scans confirmed that the leukemic infiltration in her bone marrow was asymmetric. To our knowledge, these are the first case reports of asymmetric bone marrow infiltration of blasts in acute leukemia patients after allo-HSCT. Bilateral posterior iliac crest aspirations or 18F-FDG-PET/CT scans may help distinguish such involvement.https://www.frontiersin.org/articles/10.3389/fonc.2021.626018/fullasymmetricblastsrelapseacute leukemiaallogeneic hematopoietic stem cell transplantation18F-FDG-PET/CT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Han Yan Zhenyang Zhou Zhenyang Zhou Yingying Wu Zhaodong Zhong Yong You Junxia Yao Wanxin Chen Linghui Xia Xiaotian Xia Wei Shi Wei Shi |
spellingShingle |
Han Yan Zhenyang Zhou Zhenyang Zhou Yingying Wu Zhaodong Zhong Yong You Junxia Yao Wanxin Chen Linghui Xia Xiaotian Xia Wei Shi Wei Shi Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation Frontiers in Oncology asymmetric blasts relapse acute leukemia allogeneic hematopoietic stem cell transplantation 18F-FDG-PET/CT |
author_facet |
Han Yan Zhenyang Zhou Zhenyang Zhou Yingying Wu Zhaodong Zhong Yong You Junxia Yao Wanxin Chen Linghui Xia Xiaotian Xia Wei Shi Wei Shi |
author_sort |
Han Yan |
title |
Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation |
title_short |
Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation |
title_full |
Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation |
title_fullStr |
Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation |
title_full_unstemmed |
Case Report: Asymmetric Bone Marrow Involvement in Patients With Acute Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation |
title_sort |
case report: asymmetric bone marrow involvement in patients with acute leukemia after allogeneic hematopoietic stem cell transplantation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-03-01 |
description |
After allogeneic hematopoietic stem cell transplantation (allo-HSCT), acute leukemia relapse is common, and asymmetric bone marrow recurrence hasn't been reported. Because the anatomical distribution of acute leukemia clones in the bone marrow after allo-HSCT is presumed to be diffuse, bone marrow aspirations are performed in single site. The first case was a 20-year-old man who was diagnosed with acute myelomonocytic leukemia and received haploidentical allo-HSCT. Routine bone marrow biopsy of his left posterior iliac bone marrow showed 52% leukemia blasts, while the right side had 0% blasts 10 days later. The second case was a 23-year-old woman who was diagnosed with acute B lymphoblastic leukemia and received HLA-identical sibling allo-HSCT. Although 62% of blasts were found in her left iliac marrow on day +122, 0% of blasts were found on a sample obtained from the right iliac crest on day +128. Bilateral iliac bone marrow pathology and whole-body 18F-FDG PET/CT scans confirmed that the leukemic infiltration in her bone marrow was asymmetric. To our knowledge, these are the first case reports of asymmetric bone marrow infiltration of blasts in acute leukemia patients after allo-HSCT. Bilateral posterior iliac crest aspirations or 18F-FDG-PET/CT scans may help distinguish such involvement. |
topic |
asymmetric blasts relapse acute leukemia allogeneic hematopoietic stem cell transplantation 18F-FDG-PET/CT |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.626018/full |
work_keys_str_mv |
AT hanyan casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT zhenyangzhou casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT zhenyangzhou casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT yingyingwu casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT zhaodongzhong casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT yongyou casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT junxiayao casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT wanxinchen casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT linghuixia casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT xiaotianxia casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT weishi casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation AT weishi casereportasymmetricbonemarrowinvolvementinpatientswithacuteleukemiaafterallogeneichematopoieticstemcelltransplantation |
_version_ |
1724232109210468352 |